Risk factors and molecular epidemiology of fecal carriage of carbapenem resistant Enterobacteriaceae in patients with liver disease

Table 3 Comparison of laboratory indicators between the colonization group and the non-colonization group

Variable (Referrence)	CRE colonization (N = 39)	CRE Non-colonization (N = 508)	P-value
Liver function
ALB (35.0–52.0 g/L)	30.9 ± 0.8	33.6 (30.2–38.2)	0.000
ALT (≤ 41 U/L)	51 (27–105)	45 (23–146)	0.784
AST (≤ 40 U/L)	73 (44–116)	62 (35–136)	0.468
TBIL (≤ 26.0 umol/L)	124.5 (54.7–253.7)	42.2 (15.7–163.9)	0.003
DBIL (≤ 8.0 umol/L)	108.3 (30.2–201.1)	26.6 (7.8–139.0)	0.002
IBIL (≤ 16.8 umol/L)	20.1 (10.3–47.4)	12.2 (6.4–26.8)	0.011
Coagulation Function
INR (0.80–1.20)	1.36 (1.15–1.80)	1.20 (1.05–1.51)	0.023
PTA (75.0%–125.0%)	63.9 ± 3.9	75.5 (54.0–92.0)	0.029
Blood routine examination
WBC (3.50–9.50 × 10⁹/L)	6.22 (5.04–9.99)	5.15 (3.50–7.41)	0.006
N (1.80–6.30 × 10⁹ /L)	3.91 (3.02–8.54)	3.05 (1.94–5.13)	0.002
N% (40.0%–75.0%)	71.3 ± 2.2	64.7 ± 0.7	0.008
PLT (125.0–350.0 × 10⁹ /L)	110.0 (62.0–186.0)	115.5 (65.0–186.8)	0.892
Inflammatory index
PCT (0.02–0.05 ng/ml)^a	0.29 (0.17–0.53)	0.20 (0.09–0.49)	0.082
CRP (mg/L)^b	14.5 (6.1–33.4)	8.4 (3.5–17.7)	0.010

ALB albumin, ALT alaninetransaminase, AST aspartate aminotransferase, TBIL total bilirubin, DBIL direct bilirubin, IBIL indirect bilirubin, INR: international normalized ratio, PTA prothrombin activity, WBC white blood cell count, N neutrophils, N% neutrophil percentage, PLT platelet count, PCT procalcitonin, CRP C-reactive protein
^a< 0.5 indicates low-risk severe systemic infection, 0.5—2.0 indicates moderate-risk severe systemic infection, ≥ 2.0 indicates high-risk severe systemic infection
^b1 indicates low risk of cardiovascular disease, 1—3 indicates medium risk of cardiovascular disease, > 3 indicates high risk of cardiovascular disease, > 10 indicates the possibility of infection or inflammation

ISSN: 1476-0711