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Table 1 The basic clinical data of enrolled patients

From: Metagenomic next-generation sequencing for the diagnosis of Pneumocystis jirovecii Pneumonia in critically pediatric patients

Characteristics (median[IQR] or n[%]

PCP patients (n = 17)

Non-PCP patients (n = 60)

P value

Age (years)

4.50 (3.00–7.00)

3.00 (1.00–8.00)

0.164

Male

11.00 (64.70%)

37.00 (61.70%)

0.891

PRISM

12.50 (10.00–15.00)

13.00 (10.00–17.50)

0.992

PCIS

82.00 (79.50–90.00)

87.00 (84.00–93.00)

0.100

Clinical symptoms

 Fever

13.00 (76.50%)

42.00 (71.20%)

0.903

 Cough

7.00 (41.20%)

17.00 (28.80%)

0.334

 Dyspnea

15.00 (88.20%)

16.00 (27.10%)

0.000*

Immunocompromised conditions

 Use of corticosteroids

7.00 (41.20%)

25.00 (42.40%)

0.930

 Use of immunosuppressive agents

1.00 (5.90%)

2.00 (3.40%)

1.000

 Hematologic malignancies

7.00 (41.20%)

23.00 (38.30%)

0.832

 Solid tumors

7.00 (41.20%)

19.00 (31.70%)

0.464

 Rheumatic diseases

2.00 (11.80%)

0.00 (0.00%)

0.067

Chest CT images

 Ground-glass opacity

10.00 (58.80%)

1.00 (1.90%)

0.000*

 Patchy shadowing

11.00 (64.70%)

36.00 (66.70%)

0.882

 Interstitial patterns

3.00 (17.60%)

25.00 (46.30%)

0.035*

 Pleural effusion

1.00 (5.90%)

13.00 (24.10%)

0.195

 Cystic changes

1.00 (5.90%)

0.00 (0.00%)

0.539

Indwelling gastric tube

15.00 (88.20%)

45.00 (76.30%)

0.466

Indwelling urinary catheter

14.00 (82.40%)

33.0 (55.90%)

0.048*

Indwelling vein catheter

15.00 (88.20%)

48.00 (81.40%)

0.766

Mechanical ventilation

16.00 (94.10%)

34.00 (57.60%)

0.005*

Days of mechanical ventilation

7.00 (5.00–8.50)

4.00 (0.00–9.00)

0.038*

Serum BDG (ng/L)

435.16 (152.21–600.00)

48.04 (37.50–153.90)

0.027*

LDH (U/L)

799.00 (566.00–921.00)

354.50 (236.25–712.50)

0.002*

CRP (mg/L)

57.32 (15.91–90.75)

41.13 (10.86–125.735)

0.601

PCT (ng/mL)

0.37 (0.22–0.52)

0.71 (0.27–7.06)

0.085

White blood cells (* 109/L)

4.20 (2.07–10.91)

6.39 (0.615–11.78)

0.971

Neutrophils (*109/L)

3.18 (1.15–8.66)

2.59 (0.115–7.598)

0.576

Lymphocytes (*109/L)

0.34 (0.1–0.86)

1.05 (0.36–3.65)

0.025*

CRRT

2.00 (11.80%)

5.00 (8.30%)

1.000

ARDS

14.00 (82.40%)

19.00 (31.70%)

0.000*

LOS in hospital

13.00 (9.00–16.00)

18.50 (9.75–40.25)

0.060

LOS in PICU

10.00 (8.00–14.00)

11.50 (7.75–20.00)

0.337

30 days-mortality

2.00 (11.80%)

10.00 (16.90%)

0.889

  1. IQR interquartile range, PRISM pediatric risk of mortality score, PCIS pediatric critical illness scoring, Serum BDG Serum (1,3)-β-D-glucan, CT computed tomography, LDH lactate dehydrogenase, CRP C-reactive protein, PCT procalcitonin, CRRT continuous renal replacement therapy, ARDS acute respiratory distress syndrome, LOS length of stay
  2. *P < 0.05
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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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