Table 2 Detailed characteristics of 38 patients with Edwardsiella tarda bacteremia
Age / Sex | Source of bacteremia / Intervention (if any) | Concurrent organisms from blood culture | Underlying disease | Metastatic cancer | CCI | Animal / Food exposure | Sepsis | Antibiotics | Treatment duration (d) Total (i.v. + p.o.) | 30-day survival after bacteremia | 90-day survival after bacteremia | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 79 / F | Cholangitis / ERCP (stent) | K. oxytoca, E. cloacae | Gallbladder cancer (stenting, palliative care), HT | Colon, Pancreas | 9 | No / No | Yes | C/S → C/S | 14 (14 + 0) | Yes | No (at 39 d) |
2 | 63 / F | Febrile neutropenia | None | Acute myeloid leukemia (chemotherapy) | 4 | No / No | No | VCM, IPM/CS, CAZ → CAZ | 14 (14 + 0) | Yes | Yes | |
3 | 82 / M | Cholecystitis / PTGBD | None | Gallstone | 4 | Unknown / Unknown | No | CMZ → Unknown | Unknown | Unknown | Unknown | |
4 | 69 / F | Cholangitis / ERCP (ERBD) | E. coli, K. pneumoniae | Endometrial cancer (chemotherapy, post surgery), Gallstone | None | 4 | Unknown / Raw fish (Sushi) | No | CMZ → CMZ → CEX (p.o.) | 16 (9 + 7) | Yes | Yes |
5 | 42 / F | Ovarian abscess | None | None | 0 | Unknown / Unkown | Yes | FMOX, CLDM → CMZ → LVFX (p.o.) | 17 (12 + 5) | Yes | Unknown | |
6 | 67 / M | Cholangitis | E. casseliflavus | Laryngeal cancer (chemotherapy), DM, HT | None | 5 | No / Unknown | No | CMZ → A/S | 16 (16 + 0) | Yes | Yes |
7 | 82 / M | Bacterial translocation | None | Rectal cancer (before surgery), DM, Hypertension | Liver | 11 | Unknown / Unknown | No | CTRX → CMZ | 21 (21 + 0) | Yes | Yes |
8 | 76 / F | Liver abscess | None | Lung cancer (chemotherapy/surgery), Laryngeal cancer (surgery), Gallstone, Chronic lung disease | None | 4 | Unknown / Unknown | No | CMZ → CMZ → LVFX (p.o.) | 28 (14 + 14) | Yes | Yes |
9 | 83 / M | Cholangitis / ERCP (stent) | K. pneumoniae, C. perfringens | Gastric cancer (endoscopic surgery), Stroke, HT | None | 5 | Unknown / Unknown | No | A/S → CMZ | 14 (14 + 0) | Yes | Unknown |
10 | 77 / F | Liver abscess | Prevotella sp. | Lung cancer (chemotherapy/surgery), Laryngeal cancer (surgery), Gallstone, Chronic lung disease | None | 4 | Unknown / Unknown | No | CMZ → CMZ → LVFX (p.o.) | 28 (14 + 14) | Yes | Yes |
11 | 80 / M | Cholangitis | E. coli | Cholangiocarcinoma (stenting, radiation therapy), Chronic lung disease, ITP (PSL 5 mg) | None | 7 | Unknown / Unknown | Yes | C/S → C/S → LVFX (p.o.) | 23 (6 + 17) | Yes | Yes |
12 | 75 / M | Cholecystitis / Surgery | None | Colorectal cancer (pre-existing condition), Gallstone | None | 3 | Unknown / Unknown | No | A/S → A/S → A/C (p.o.) | 14 (10 + 4) | Yes | Yes |
13 | 75 / F | Cholangitis | None | Gallstone, HT, DM | 4 | Unknown / No | No | CMZ → CMZ → LVFX (p.o.) | 11 (4 + 7) | Yes | Yes | |
14 | 85 / F | Cholangitis / ERCP (stent) | K. pneumoniae | Pancreatic cancer (stenting, palliative care), HT | Liver | 10 | No / No | Yes | P/T → P/T | 3 (3 + 0) | No (at 3 d) | No |
15 | 77 / M | Cholecystitis / ERCP (stent) | None | Gallstone, Chronic liver disease (HCV) | 4 | Unknown / Unknown | No | CMZ → CMZ | 9 (9 + 0) | Yes | Unknown | |
16 | 80 / M | Cholangitis / ERCP (stent) | E. casseliflavus, K. oxytoca | Pancreatic cancer (chemotherapy, drainage tube placement), DM, HT, Chronic liver disease (HCV) | None | 7 | Unknown / Unknown | No | IPM/CS → CTX, ABPC | 7 (7 + 0) | Yes | Yes |
17 | 80 / M | Cholangitis / ERCP (stent) | E. aerogenes, A. hydrophila | Pancreatic cancer (chemotherapy, stenting), DM, HT, Chronic liver disease (HCV) | None | 7 | No / No | No | A/S → A/S | 8 (8 + 0) | Yes | Yes |
18 | 68 / M | Cholecystitis / Surgery | None | Gallstone, Chronic liver disease (HBV) | 3 | Unknown / Unknown | No | C/S → C/S | 5 (5 + 0) | Yes | Yes | |
19 | 83 / M | Cholangitis ERCP (ERBD) | E. casseliflavus, K. pneumoniae, A. hydrophila | Pancreatic cancer (drainage tube, palliative care), Dementia | None | 7 | Unknown / Unknown | No | A/S → P/T | 12 (12 + 0) | No (at 27 d) | No |
20 | 70 / M | Intra-abdominal abscess / Local drainage | None | Rectal cancer (palliative care) | Liver | 9 | Unknown / Unknown | Yes | CAZ, MNZ → CAZ, MNZ | 14 (7 + 7) | Yes | No (at 73 d) |
21 | 75 / M | Cholangitis / PTCD | None | Pancreatic cancer (before chemotherapy), HT, DM, Stroke | None | 7 | Unknown / Unknown | Yes | IPM/CS → IPM/CS | 12 (12 + 0) | Yes | No (at 54 d) |
22 | 74 / M | Spontaneous bacterial peritonitis | None | Gastric cancer (diagnosed at admission), DM | Liver | 9 | Unknown / Unknown | No | CTRX → CTRX → LVFX (p.o.) | 11 (4 + 7) | Yes | Yes |
23 | 68 / M | Cholangitis / ERCP (stent) | E. coli | Cardiovascular disease, Stroke, HT, Gallstone | 3 | Unknown / Unknown | No | CMZ → CMZ → A/C (p.o.) | 14 (7 + 7) | Yes | Yes | |
24 | 89 / F | Cholangitis / ERCP (stent) | E. coli, K. oxytoca | Gallstone, Cholangitis (stenting), Cardiovascular disease, Chronic kidney disease | None | 5 | Unknown / Unknown | Yes | MEPM → CMZ → TMP/SMX (p.o.) | 13 (9 + 4) | Unknown | Unknown |
25 | 74 / M | Cholangitis, Cholecystitis / Surgery | None | Prostate cancer (surgery), Gallstone, Cholangitis, Cardiovascular disease, HT, Chronic lung disease | None | 4 | Unknown / Unknown | Yes | A/S → CMZ → CEX (p.o.) | 15 (12 + 3) | Yes | Yes |
26 | 75 / M | Cholangitis | None | Cholangiocarcinoma (drainage tube), DM, HT | None | 6 | No / Unknown | No | CMZ → CMZ → A/C (p.o.) | 14 (6 + 8) | Yes | Yes |
27 | 83 / F | Liver abscess, Cholangitis / ERCP (stent) | None | Gallstone, SLE, HT | 5 | Unknown / Unknown | No | CMZ → ABPC → AMPC (p.o.) | 28 (7 + 21) | Yes | Yes | |
28 | 85 / F | Cholecystitis / PTGBD | None | Gallstone, Cholangitis, HT, Stroke | 5 | Unknown / Unknown | No | MEPM → A/S | 10 (10 + 0) | Yes | Yes | |
29 | 90 / M | Unknown origin | K. oxytoca | Lung cancer (palliative care), Stroke, HT, Dementia, Gallstone | None | 8 | Unknown / Unknown | Yes | CMZ → CEZ → CFPM | 14 (14 + 0) | Yes | No (at 53 d) |
30 | 71 / M | Appendicitis / Surgery | None | Cardiovascular disease, Diabetes, HT, Chronic lung disease, Chronic kidney disease | 6 | Unknown / Unknown | No | CMZ → CMZ → LVFX (p.o.), MNZ (p.o.) | 14 (7 + 7) | Yes | Yes | |
31 | 87 / F | Cholangitis | K. pneumoniae | HT, Chronic kidney disease, Gallstone | 4 | Unknown / Unknown | No | CMZ → P/T | 25 (25 + 0) | Yes | Yes | |
32 | 98 / F | Cholangitis / ERCP (EST) | None | Pancreatic cancer (palliative care), Gallstone, Stroke, HT, Chronic lung disease, Dementia | None | 9 | Unknown / Unknown | No | A/S → A/S → LVFX (p.o.) | 10 (5 + 5) | Unknown | Unknown |
33 | 79 / M | Intra-abdominal abscess, Peritonitis / Surgery | None | Rectal cancer (chemotherapy) | None | 5 | Unknown / Unknown | No | CMZ → CMZ | 15 (15 + 0) | No (at 16 d) | No |
34 | 25 / F | Intrauterine infection / Surgery | None | Sigmoid sinus thrombosis | 1 | Goldfish, Turtle / No | No | CMZ → CEX (p.o.) | 14 (7 + 7) | Yes | Yes | |
35 | 78 / M | Cholangitis, Intra-abdominal abscess | K. pneumoniae, E. faecalis | DM, Pancreatic cancer (chemotherapy), | Liver | 10 | Unknown / Unknown | No | MEPM | 28 (28 + 0) | Yes | No (at 88 d) |
36 | 77 / F | Cholecystitis / PTGBD | None | AIH (PSL 4 mg), Lung cancer (chemotherapy), Cholecystitis | None | 5 | Unknown / Unknown | No | MEPM | 11 (11 + 0) | Yes | Yes |
37 | 83 / M | Liver abscess | K. pneumoniae | Prostatic cancer (chemotherapy), Chronic lung disease, Gallstone | None | 7 | No / Unknown | No | CMZ → A/C (p.o.) | 35 (14 + 21) | Yes | Yes |
38 | 92 / F | Cholangitis | None | Gallbladder cancer (surgery), Stroke, HT | None | 4 | No / Unknown | No | CMZ → CEX (p.o.) | 15 (10 + 5) | Yes | Unknown |