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Table 1 Baseline Characteristics

From: The clinical outcomes of high neutralizing antibodies titer convalescent plasma therapy in early developed severe COVID-19 patients; a case–control study

Variable

CPT [n = 52; n (%)]

Standard Care [n = 55; n (%)]

P-value

Sex

  

0.482a

Male

22 (42.31)

27 (49.09)

Female

30 (57.69)

28 (50.91)

Age in years, median (IQR)

61 (45–66.5)

71 (61–77)

 < 0.001b

BMI in kg/m2, median (IQR)

26.67 (23.53–31.63)

25.63 (22.04–29.52)

0.257c

 < 31

24 (60.00)

38 (80.85)

0.106d

31–35

10 (25.00)

6 (12.77)

 > 35

6 (15.00)

3 (6.38)

Comorbidity

43 (82.69)

36 (69.23)

0.108a

Hypertension

29 (55.77)

32 (61.54)

0.550a

Diabetes Mellitus

25 (48.08)

21 (40.38)

0.430a

Cerebrovascular disease

1 (1.92)

1 (1.92)

1.000d

Chronic kidney disease

5 (9.62)

10 (19.23)

0.163a

End stage renal disease

1 (1.92)

1 (1.92)

1.000d

Cancer

1 (1.92)

1 (1.92)

1.000d

Ischemic Heart Disease

1 (1.92)

6 (11.54)

0.112d

Others

3 (5.76)

2 (3.64)

0.679b

Duration from the onset of symptoms to the admission day (days), median (IQR)

5.5 (0–19)

4 (0–16)

0.067b

Receiving dexamethasone

52/52 (100%)

55/55 (100%)

1.000

Receiving RdRp inhibitor treatment

52/52 (100%)

55/55 (100%)

1.000

Day of dexamethasone treatment, median (IQR)

8 (0–14)

6 (1–20)

0.507c

Day of RdRp inhibitors treatment, median (IQR)

10 (5–10)

5.5 (1–10)

0.016c

Day of CPT after the onset of symptoms, median (IQR)

9 (6–13)

0

Day of CPT after admission, median (IQR)

2 (1–3)

0

The lowest SpO2 from admission to deterioration, median (IQR)

91 (68–95)

87 (15–95)

0.007b

Duration from the day of admission to critical illness (days), median (IQR)

5 (0–19)

0 (0–13)

 < 0.001b

  1. aChi-square test
  2. bMann-Whitney U test
  3. cIndependent t-test
  4. dFisher’s exact test
  5. BMI body mass index, CPT convalescent plasma therapy, IQR interquartile range, RdRp RNA-dependent RNA polymerase, SpO2 oxygen saturation