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Fig. 8 | Annals of Clinical Microbiology and Antimicrobials

Fig. 8

From: Curcumin and capsaicin regulate apoptosis and alleviate intestinal inflammation induced by Clostridioides difficile in vitro

Fig. 8

A schematic diagram which demonstrates the potential biological impact of capsaicin (CAP) and curcumin (CCM) on C. difficile toxin-mediated inflammation. Exposure of intestinal epithelial cells (IECs) to CCM and CAP can lead to inhibition of TGF-β1 and Smad3, respectively, which may result in maintaining the integrity of the intestinal epithelial tight junctions (TJs) barrier. In addition, CAP and CCM can alleviate host inflammatory responses induced by TcdA and TcdB toxins probably through downregulation of NF-κB and TNF-α. On the other hand, they may induce apoptosis via downregulation of BCL-2 as an anti-apoptotic factor. Notes: red arrows indicate inhibitory actions, whereas blue arrows indicate enhancing actions

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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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