Evaluation of GeneXpert EV assay for the rapid diagnosis of enteroviral meningitis: a systematic review and meta-analysis

Table 1 Summary of the characteristics of included studies

First author	Year	Country	Study design	The specimen source	Age of patients	Patients with gender	Initial sample size	Research involved	Test method
Frederick S Nolte [16]	2010	Georgia	Prospective and retrospective	CSF	156neonates 227Children 53Adults	ALL	475	416	GXEA
Katja Seme (a) [19]^*	2008	The Republic of Slovenia	Prospective	CSF	UC	UC	162	162	GXEA
Katja Seme (b) [19]^$	2008	The Republic of Slovenia	Prospective	CSF	UC	UC	162	162	GXEA
Marlowe, E. M. [15]	2008	USA	Retrospective	CSF	UC	UC	138	136	GXEA
Ninove, L. [12]	2011	France	Prospective	CSF	< 1 year,1–4 years,5–14 years,15–24 years,25–49 years, > 50 years	ALL	310	310	GXEA
Ninove, Laetitia [12]	2010	France	Prospective	CSF	ALL	UC	469	390	GXEA
S.C.M. de Crom [21]	2011	Netherlands	Retrospective	CSF	0–84.10	ALL	116	232	GXEA
Slika, S. [22]	2012	USA	Prospective	CSF	UC	UC	220	220	GXEA

First author	Positive	Negative	Reference standard	Positive	Negative	TP	FP	TN	FN
Frederick S Nolte [16]	114	312	RT-PCR	94	322	90	14	308	4
Katja Seme (a) [19]^*	75	87	RT-PCR	83	79	75	0	79	8
Katja Seme (b) [19]^$	82	80	RT-PCR	83	79	82	0	79	1
Marlowe, E. M. [15]	25	111	RT-PCR	25	111	25	0	111	0
Ninove, L. [12]	85	174	RT-PCR	81	225	81	0	172	2
Ninove, Laetitia [12]	109	289	RT-PCR	108	352	105	2	283	0
S.C.M. de Crom [21]	32	185	RT-PCR	40	192	32	0	178	7
Slika, S. [22]	42	178	RT-PCR	42	178	42	0	178	0

CSF, cerebrospinal fluid; UC, unclear; TP, ture positive; FP, false positive; TN, ture negative; FN, false negative
^*In this search, preliminary results using RT-PCR and GeneXpert EV assay detection
^$In this search, final results were obtained by reexamining the preliminary negative and uncertain results

ISSN: 1476-0711