Table 2 Comparison of detection results against bacteria and antimicrobial resistance between the BioFire FilmArray Pneumonia Panela and culture-based methods
Bacterium and antimicrobial resistance | PN+, CM+ | PN+, CM− | PN−, CM+ | PN−, CM− | PPA (95% CI) | NPA (95% CI) |
|---|---|---|---|---|---|---|
Bacterium | ||||||
A. calcoaceticus-baumannii complex | 0 | 6 | 0 | 51 | – | 89.5 (78.5–96.0) |
E. cloacae complex | 1 | 5 | 0 | 51 | 100.0 (2.5–100.0) | 91.1 (80.4–97.0) |
E. coli | 1 | 3 | 0 | 53 | 100.0 (2.5–100.0) | 94.6 (85.1–98.9) |
H. influenzae | 5 | 1 | 0 | 51 | 100.0 (47.8–100.0) | 98.1 (89.7–100.0) |
K. aerogenes | 0 | 4 | 0 | 53 | – | 93.0 (83.0–98.1) |
K. oxytoca | 1 | 0 | 0 | 56 | 100.0 (2.5–100.0) | 100.0 (93.6–100.0) |
K. pneumoniae group | 3 | 7 | 0 | 47 | 100.0 (29.2–100.0) | 87.0 (75.1–94.6) |
M. catarrhalis | 0 | 2 | 0 | 55 | – | 96.5 (87.9–99.6) |
Proteus species | 0 | 0 | 0 | 57 | – | 100.0 (93.7–100.0) |
P. aeruginosa | 8 | 9 | 0 | 40 | 100.0 (63.1–100.0) | 81.6 (68.0–91.2) |
S. marcescens | 1 | 2 | 0 | 54 | 100.0 (2.5–100.0) | 96.4 (87.7–99.6) |
S. aureus | 3 | 14 | 0 | 40 | 100.0 (29.2–100.0) | 74.1 (60.3–85.0) |
S. agalactiae | 0 | 3 | 0 | 54 | – | 94.7 (85.4–98.9) |
S. pneumoniae | 2 | 2 | 0 | 53 | 100.0 (15.8–100.0) | 96.4 (87.5–99.6) |
S. pyogenes | 0 | 1 | 0 | 56 | – | 98.2 (90.6–100.0) |
Total | 25 | 59 | 0 | 771 | 100.0 (86.3–100.0) | 92.9 (90.9–94.5) |
Antimicrobial resistance | ||||||
MRSAb | 0 | 5 | 0 | 52 | – | 91.2 (80.7–97.1) |
ESBL producerc | 2 | 2 | 0 | 53 | 100.0 (15.8–100.0) | 96.4 (87.5–99.6) |
Total | 2 | 7 | 0 | 105 | 100.0 (15.8–100.0) | 93.8 (87.5–97.5) |