Table 4 Case studies of N. otitidiscaviarum resistant to TMP-SMX
References | Years | Age/gender | Immune Status | Drug Susceptibility | Treatment | Outcome |
|---|---|---|---|---|---|---|
Matsu et al. [19] | 2000 | 74M | Immunocompetent (Farmer) | Resistant to: TMP-SMX, Penicillin, Piperacillin, Imipenem, Ceftazidime. Susceptible to: Amikacin, Minocycline, Clarithromycin | TMP-SMX à Clarithromycin + Amikacin | Recovered |
Yoshida et al. [30] | 2004 | 69M | On Corticosteroid therapy | Resistant to: Ampicillin, Piperacillin, Cefazolin, Imipenem, minocycline, Vancomycin, TMP-SMX, Erythromycin. Susceptible to: Levofloxacin, Gentamicin and Levofloxacin | Imipenem + TMP-SMX à TMP-SMX + Gentamicin | Recovered |
Mahgoub et al. [17] | 2016 | 41F | Immunocompetent | Resistant to: Azithromycin, Ceftazidime, Penicillin, Rifampicin and TMP-SMX. Susceptible to: Amikacin, Ciprofloxacin, Meropenem and Streptomycin | TMP-SMX + Amikacin + Imipenem à Ceftriaxone + Amikacin + Ciprofloxacin | Recovered |
Candel et al. [13] | 2017 | 79M | On Corticosteroid therapy | Resistant to: TMP-SMX. Susceptible to Aminoglycosides, Beta-lactams and Carbapenem | Levofloxacin + Vancomycin + Tobramycin | Died |
Princess et al. [21] | 2018 | 51F | On Corticosteroid therapy | Resistant to: TMP-SMX, Amoxicillin, Clavulanate. Susceptible to: Amikacin, Ciprofloxacin, Linezolid, Imipenem and Ceftriaxone | Azithromycin + Doxycycline à TMP-SMX + Imipenem | Died |
Saksena et al. [24] | 2020 | 74M | Immunocompetent | Resistant to: Ampicillin, Amoxicillin-Clavulanate, Erythromycin, TMP-SMX and imipenem. SusceptibleTo: Amikacin, Linezolid, Ciprofloxacin, and Gentamicin | Amoxicillin-Clavulanate + Azithromycin à TMP-SMX | Died |
Saksena et al. [24] | 2020 | 74F | Immunocompetent | Resistant to: Ampicillin, Amoxicillin-Clavulanate, Erythromycin, TMP-SMX and imipenem. Susceptible to: Amikacin, Linezolid, Ciprofloxacin, and Gentamicin | Meropenem + Colistin à TMP-SMX added | Died |