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Table 4 Case studies of N. otitidiscaviarum resistant to TMP-SMX

From: A fatal case of disseminated nocardiosis due to Nocardia otitidiscaviarum resistant to trimethoprim–sulfamethoxazole: case report and literature review

References Years Age/gender Immune Status  Drug Susceptibility Treatment Outcome
Matsu et al.  [19] 2000 74M Immunocompetent (Farmer) Resistant to: TMP-SMX, Penicillin, Piperacillin, Imipenem, Ceftazidime. Susceptible to: Amikacin, Minocycline, Clarithromycin TMP-SMX à Clarithromycin + Amikacin Recovered
Yoshida et al. [30] 2004 69M On Corticosteroid therapy Resistant to: Ampicillin, Piperacillin, Cefazolin, Imipenem, minocycline, Vancomycin, TMP-SMX, Erythromycin. Susceptible to: Levofloxacin, Gentamicin and Levofloxacin Imipenem + TMP-SMX à TMP-SMX + Gentamicin Recovered
Mahgoub et al. [17] 2016 41F Immunocompetent Resistant to: Azithromycin, Ceftazidime, Penicillin, Rifampicin and TMP-SMX. Susceptible to: Amikacin, Ciprofloxacin, Meropenem and Streptomycin TMP-SMX + Amikacin + Imipenem à Ceftriaxone + Amikacin + Ciprofloxacin Recovered
Candel et al. [13] 2017 79M On Corticosteroid therapy Resistant to: TMP-SMX. Susceptible to Aminoglycosides, Beta-lactams and Carbapenem Levofloxacin + Vancomycin + Tobramycin Died
Princess et al.  [21] 2018 51F On Corticosteroid therapy Resistant to: TMP-SMX, Amoxicillin, Clavulanate. Susceptible to: Amikacin, Ciprofloxacin, Linezolid, Imipenem and Ceftriaxone Azithromycin + Doxycycline à TMP-SMX + Imipenem Died
Saksena et al. [24] 2020 74M Immunocompetent Resistant to: Ampicillin, Amoxicillin-Clavulanate, Erythromycin, TMP-SMX and imipenem. SusceptibleTo: Amikacin, Linezolid, Ciprofloxacin, and Gentamicin Amoxicillin-Clavulanate + Azithromycin à TMP-SMX Died
Saksena et al. [24] 2020 74F Immunocompetent Resistant to: Ampicillin, Amoxicillin-Clavulanate, Erythromycin, TMP-SMX and imipenem. Susceptible to: Amikacin, Linezolid, Ciprofloxacin, and Gentamicin Meropenem + Colistin à TMP-SMX added Died
  1. M, male; F, female; TMP-SMX, trimethoprim–sulfamethoxazole; GCS, Glasgow coma scale