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Table 3 Typical in-vitro antimicrobial susceptibility patterns of various Nocardia species (Adapted from Manual of clinical microbiology [40])

From: A fatal case of disseminated nocardiosis due to Nocardia otitidiscaviarum resistant to trimethoprim–sulfamethoxazole: case report and literature review

Drug

N. abscessus

N. brasiliensis

N. brevicatena and N. paucivorans

N. cyriacigeorgica

N. farcinica

N. nova complex

N. otitidiscaviarum

N. pseudobrasiliensis

N. transvalensis complex

Amoxicillin–Clavulanic Acid

S

S

S

R

–

R

R

R

–

Amikacin

S

–

S

S

S

S

S

–

R

Ceftriaxone

S

–

S

S

R

S

R

–

S

Ciprofloxacin

R

R

S

R

S

–

S

S

S

Clarithromycin

R

R

R

R

R

S

–

S

R

Gentamicin

–

–

R

–

R

–

S

–

R

Imipenem

R

–

R

S

S

S

R

–

S

Linezolid

S

S

S

S

S

S

S

S

S

Minocycline

–

S

–

–

–

–

–

R

–

Sulfamethoxazole

–

S

–

–

–

–

S

S

–

Tobramycin

–

–

–

–

R

–

–

–

R

  1. S susceptible, R Resistant
  2. The optimal antimicrobial management for N. otitidiscaviarum is still not clearly defined, however, combined treatment is suggested for disseminated and severe disease. In our case, the isolated N. otitidiscaviarum was susceptible to Linezolid and Amikacin and was resistant to TMP-SMX, Ciprofloxacin, Imipenem, Cefepime, Cefoxitin, Amoxicillin-Clavulanic acid, Clarithromycin and Tobramycin. Seven cases were similarly reported with resistance to TMP-SMX [17, 19, 21, 24, 28, 30] with four cases reported in immunocompetent patients [17, 19, 24], and one infecting a farmer [19], details of these studies are described in Table 4
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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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