Effective anti-mycobacterial treatment for BCG disease in patients with Mendelian Susceptibility to Mycobacterial Disease (MSMD): a case series

Mahdaviani, Seyed Alireza; Fallahi, Mazdak; Jamee, Mahnaz; Marjani, Majid; Tabarsi, Payam; Moniri, Afshin; Farnia, Parisa; Daneshmandi, Zahra; Parvaneh, Nima; Casanova, Jean-Laurent; Bustamante, Jacinta; Mansouri, Davood; Velayati, Ali Akbar

doi:10.1186/s12941-022-00500-y

Annals of Clinical Microbiology and Antimicrobials

Table 2 Antibiotic susceptibility, therapeutic modalities, and outcomes

From: Effective anti-mycobacterial treatment for BCG disease in patients with Mendelian Susceptibility to Mycobacterial Disease (MSMD): a case series

Pt No	Susceptibility profile					First-line therapy	Final therapy	IFN-γ	Surgery	Outcome (Cause of death)
Pt No	RIF	INH	ETB	AMIK	CIP	First-line therapy	Final therapy	IFN-γ	Surgery	Outcome (Cause of death)
1	R	S	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Ofloxacin, Clarithromycin	Isoniazid, Rifampin, Ethambutol, Ofloxacin, Dapsone, Cycloserine	Yes	Abdominal surgery, Lymphadenectomy	Deceased (Respiratory failure)
2	S	S	S	S	S	Isoniazid, Rifampin, Ethambutol, Amikacin, Clarithromycin (~ Pyrazinamide)	Isoniazid, Rifampin, Ethambutol, Amikacin, Ofloxacin	Yes	No	Alive
3	R	R	S	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin (~ Amikacin and Ethionamide)	Levofloxacin, Clarithromycin, Ethambutol, Cycloserine, Ethionamide, Linezolid, Clofazimine (~ Amikacin and Prothionamide)	Yes	Abdominal surgery	Alive
4	N/D	N/D	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ciprofloxacin	Isoniazid, Rifampin, Ethambutol, Clarithromycin, Levofloxacin, Amikacin	Yes	Lymphadenectomy	Alive
5	N/D	N/D	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin	Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin	No	No	Alive
6	S	S	S	N/D	N/D	Rifampin, Ethambutol, Pyrazinamide, Clarithromycin	Isoniazid, Rifampin, Ethambutol, Levofloxacin	Yes	No	Alive
7	S	S	S	S	S	Ethambutol, Levofloxacin, Prothionamide, Cycloserine (~ Amikacin)	Isoniazid, Ethambutol, Levofloxacin	No	No	Alive
8	N/D	N/D	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Amikacin, Clarithromycin, Ofloxacin (~ Dapsone, Clofazimine)	Ethambutol, Amikacin, Clarithromycin, Levofloxacin, Fluvoxamine, Prothionamide, Cycloserine	Yes	Abdominal surgery, lymphadenectomy	Alive
9	S	S	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ciprofloxacin	Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ciprofloxacin	Yes	Lymphadenectomy	Alive
10	R	R	S	S	R	Isoniazid, Rifampin, Ethambutol, Amikacin, Ofloxacin, Clarithromycin (~ Streptomycin, Prothionamide)	Amikacin, Levofloxacin, Cycloserine, Ethionamide, Clofazimine, Meropenem, Co-Amoxiclav	Yes	Abdominal surgery (Psoas abscess drainage)	Alive
11	R	S	S	S	S	Isoniazid, Rifampin, Ethambutol, Pyrazinamide	Isoniazid, Rifampin, Ethambutol, Levofloxacin, Co-Trimoxazole (~ Amikacin)	Yes	No	Alive
12	N/D	N/D	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Clarithromycin (~ Cycloserine)	Isoniazid, Rifampin, Ethambutol, Clarithromycin	Yes	No	Alive
13	N/D	N/D	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Ofloxacin, Clarithromycin	Isoniazid, Rifampin	No	Lymphadenectomy	Alive
14	N/D	N/D	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin	Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin	No	No	Alive
15	N/D	N/D	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Clarithromycin	Isoniazid, Rifampin, Ethambutol, Clarithromycin	Yes	No	Alive
16	N/D	N/D	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Clarithromycin	Isoniazid, Rifampin, Ethambutol, Amikacin, Levofloxacin	No	Lymphadenectomy	Alive
17	S	S	S	S	S	Isoniazid, Rifampin, Ethambutol, Levofloxacin, Amikacin (~ Meropenem, Linezolid)	Isoniazid, Rifampin, Ethambutol, Levofloxacin, Amikacin, Cycloserine	Yes	Central vein catheterization	Alive
18	R	S	S	S	S	Isoniazid, Rifampin, Ethambutol	Rifampin, Levofloxacin, Cycloserine, Isoniazid, Ethambutol, Linezolid	No	Lymphadenectomy	Alive
19	N/D	N/D	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Clarithromycin, Levofloxacin	Isoniazid, Rifampin, Ethambutol, Clarithromycin, Levofloxacin	Yes	No	Alive
20	R	S	R	S	S	Isoniazid, Ethambutol, Amikacin, Levofloxacin	Isoniazid, Ethambutol, Amikacin, Levofloxacin	Yes	Abdominal surgery, Lymphadenectomy	Alive
21	N/D	N/D	N/D	N/D	N/D	Isoniazid, Rifampin, Ethambutol	Rifampin, Isoniazid, Ethambutol	No	No	Alive
22	S	S	S	S	S	Isoniazid, Rifampin, Ethambutol, Ciprofloxacin	Rifampin, Isoniazid, Ethambutol, Levofloxacin, Amikacin	No	No	Alive
23	S	S	S	N/D	N/D	Isoniazid, Rifampin, Ethambutol, Levofloxacin	Isoniazid, Rifampin	No	Lymphadenectomy	Alive
24	S	S	S	N/D	N/D	Rifampin, Isoniazid, Levofloxacin, Amikacin	Rifampin, Isoniazid, Levofloxacin, Amikacin	No	Abdominal surgery, Lymphadenectomy	Deceased (Severe BCG infection)

~ Used for a short time and discontinued
AMIK; amikacin, CIP; ciprofloxacin, ETB; ethambutol, N/D; not determined, INH; isoniazid, RIF; rifampin, S; sensible, R; resistant

Back to article page

ISSN: 1476-0711

Contact us

Submission enquiries: journalsubmissions@springernature.com