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Table 2 Antibiotic susceptibility, therapeutic modalities, and outcomes

From: Effective anti-mycobacterial treatment for BCG disease in patients with Mendelian Susceptibility to Mycobacterial Disease (MSMD): a case series

Pt No Susceptibility profile First-line therapy Final therapy IFN-γ Surgery Outcome (Cause of death)
RIF INH ETB AMIK CIP
1 R S N/D N/D N/D Isoniazid, Rifampin, Ethambutol, Ofloxacin, Clarithromycin Isoniazid, Rifampin, Ethambutol, Ofloxacin, Dapsone, Cycloserine Yes Abdominal surgery, Lymphadenectomy Deceased (Respiratory failure)
2 S S S S S Isoniazid, Rifampin, Ethambutol, Amikacin, Clarithromycin (~ Pyrazinamide) Isoniazid, Rifampin, Ethambutol, Amikacin, Ofloxacin Yes No Alive
3 R R S N/D N/D Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin (~ Amikacin and Ethionamide) Levofloxacin, Clarithromycin, Ethambutol, Cycloserine, Ethionamide, Linezolid, Clofazimine (~ Amikacin and Prothionamide) Yes Abdominal surgery Alive
4 N/D N/D N/D N/D N/D Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ciprofloxacin Isoniazid, Rifampin, Ethambutol, Clarithromycin, Levofloxacin, Amikacin Yes Lymphadenectomy Alive
5 N/D N/D N/D N/D N/D Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin No No Alive
6 S S S N/D N/D Rifampin, Ethambutol, Pyrazinamide, Clarithromycin Isoniazid, Rifampin, Ethambutol, Levofloxacin Yes No Alive
7 S S S S S Ethambutol, Levofloxacin, Prothionamide, Cycloserine (~ Amikacin) Isoniazid, Ethambutol, Levofloxacin No No Alive
8 N/D N/D N/D N/D N/D Isoniazid, Rifampin, Ethambutol, Amikacin, Clarithromycin, Ofloxacin (~ Dapsone, Clofazimine) Ethambutol, Amikacin, Clarithromycin, Levofloxacin, Fluvoxamine, Prothionamide, Cycloserine Yes Abdominal surgery, lymphadenectomy Alive
9 S S N/D N/D N/D Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ciprofloxacin Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ciprofloxacin Yes Lymphadenectomy Alive
10 R R S S R Isoniazid, Rifampin, Ethambutol, Amikacin, Ofloxacin, Clarithromycin (~ Streptomycin, Prothionamide) Amikacin, Levofloxacin, Cycloserine, Ethionamide, Clofazimine, Meropenem, Co-Amoxiclav Yes Abdominal surgery (Psoas abscess drainage) Alive
11 R S S S S Isoniazid, Rifampin, Ethambutol, Pyrazinamide Isoniazid, Rifampin, Ethambutol, Levofloxacin, Co-Trimoxazole (~ Amikacin) Yes No Alive
12 N/D N/D N/D N/D N/D Isoniazid, Rifampin, Ethambutol, Clarithromycin (~ Cycloserine) Isoniazid, Rifampin, Ethambutol, Clarithromycin Yes No Alive
13 N/D N/D N/D N/D N/D Isoniazid, Rifampin, Ethambutol, Ofloxacin, Clarithromycin Isoniazid, Rifampin No Lymphadenectomy Alive
14 N/D N/D N/D N/D N/D Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin Isoniazid, Rifampin, Ethambutol, Clarithromycin, Ofloxacin No No Alive
15 N/D N/D N/D N/D N/D Isoniazid, Rifampin, Ethambutol, Clarithromycin Isoniazid, Rifampin, Ethambutol, Clarithromycin Yes No Alive
16 N/D N/D N/D N/D N/D Isoniazid, Rifampin, Ethambutol, Clarithromycin Isoniazid, Rifampin, Ethambutol, Amikacin, Levofloxacin No Lymphadenectomy Alive
17 S S S S S Isoniazid, Rifampin, Ethambutol, Levofloxacin, Amikacin (~ Meropenem, Linezolid) Isoniazid, Rifampin, Ethambutol, Levofloxacin, Amikacin, Cycloserine Yes Central vein catheterization Alive
18 R S S S S Isoniazid, Rifampin, Ethambutol Rifampin, Levofloxacin, Cycloserine, Isoniazid, Ethambutol, Linezolid No Lymphadenectomy Alive
19 N/D N/D N/D N/D N/D Isoniazid, Rifampin, Ethambutol, Clarithromycin, Levofloxacin Isoniazid, Rifampin, Ethambutol, Clarithromycin, Levofloxacin Yes No Alive
20 R S R S S Isoniazid, Ethambutol, Amikacin, Levofloxacin Isoniazid, Ethambutol, Amikacin, Levofloxacin Yes Abdominal surgery, Lymphadenectomy Alive
21 N/D N/D N/D N/D N/D Isoniazid, Rifampin, Ethambutol Rifampin, Isoniazid, Ethambutol No No Alive
22 S S S S S Isoniazid, Rifampin, Ethambutol, Ciprofloxacin Rifampin, Isoniazid, Ethambutol, Levofloxacin, Amikacin No No Alive
23 S S S N/D N/D Isoniazid, Rifampin, Ethambutol, Levofloxacin Isoniazid, Rifampin No Lymphadenectomy Alive
24 S S S N/D N/D Rifampin, Isoniazid, Levofloxacin, Amikacin Rifampin, Isoniazid, Levofloxacin, Amikacin No Abdominal surgery, Lymphadenectomy Deceased (Severe BCG infection)
  1.  ~ Used for a short time and discontinued
  2. AMIK; amikacin, CIP; ciprofloxacin, ETB; ethambutol, N/D; not determined, INH; isoniazid, RIF; rifampin, S; sensible, R; resistant