Effective anti-mycobacterial treatment for BCG disease in patients with Mendelian Susceptibility to Mycobacterial Disease (MSMD): a case series

Mahdaviani, Seyed Alireza; Fallahi, Mazdak; Jamee, Mahnaz; Marjani, Majid; Tabarsi, Payam; Moniri, Afshin; Farnia, Parisa; Daneshmandi, Zahra; Parvaneh, Nima; Casanova, Jean-Laurent; Bustamante, Jacinta; Mansouri, Davood; Velayati, Ali Akbar

doi:10.1186/s12941-022-00500-y

Annals of Clinical Microbiology and Antimicrobials

Table 1 Summary of demographic and clinical features of MSMD patients

From: Effective anti-mycobacterial treatment for BCG disease in patients with Mendelian Susceptibility to Mycobacterial Disease (MSMD): a case series

Patient No	Mutated Gene	Sex	Ethnicity	Age at BCG disease (month)	Age at MSMD diagnosis (year)	BCG disease type	Coinfections	Other comorbidities	References
1	IL23R	Male	Azeri	0.48	5.00	Disseminated	No	Lung involvement, Splenomegaly, Enteropathy	[18, 33]
2	IL12B	Female	Baluch	0.36	2.05	Disseminated	Candida	No	[18]
3	IL12RB1	Female	Persian	0.72	2.01	Disseminated	Salmonella, Klebsiella	Lung involvement	[18, 24]
4	IL12B	Female	Baluch	0.48	0.04	Disseminated	Salmonella, Candida	No	[18]
5	IL12RB1	Male	Persian	1.32	0.11	Disseminated	No	No	[18]
6	IL12B	Female	Baluch	6.00	3.00	Disseminated	Candida	No	[18]
7	IL23R	Male	Persian	3.60	7.00	Disseminated	No	No	[18]
8	IL12B	Female	Baluch	0.00	12.00	Disseminated	No	Vasculitis	[18]
9	IL12RB1	Female	Kurd	0.36	0.05	Disseminated	Salmonella	Splenomegaly	[18]
10	TYK2	Male	Baluch	0.36	7.00	Disseminated	No	Unilateral paresthesia, Lung involvement	[18, 34]
11	IL12RB1	Male	Persian	25.20	6.00	Disseminated	Salmonella	No	[18]
12	IL12RB1	Male	Persian	0.36	0.08	Disseminated	No	Splenomegaly	[18]
13	IL12RB1	Female	Persian	0.48	0.04	Disseminated	No	Splenomegaly	[18]
14	IL12B	Male	Baluch	0.36	7.00	Disseminated	No	Splenomegaly	[18]
15	IL12RB1	Male	Persian	4.80	2.00	Localized	No	No	(18)
16	IL12B	Male	Baluch	3.60	9.20	Localized	No	No	Unpublished
17	N/D	Male	Afghan	7.20	1.20	Localized	Klebsiella, Enterobacter	No	Unpublished
18	N/D	Male	Azeri	2.40	1.00	Localized	No	Splenomegaly, Enteropathy	Unpublished
19	N/D	Female	Afghan	2.40	2.50	Localized	Candida	Enteropathy, Atopy	Unpublished
20	IL12RB1	Female	Azeri	3.00	0.30	Localized	No	Septic arthritis, Atopy, Lung involvement, Splenomegaly	Unpublished
21	IL12RB1	Female	Azeri	42.00	3.00	Disseminated	No	Enteropathy, Atopy, Lung involvement	Unpublished
22	IL12RB1	Female	Azeri	3.60	2.80	Localized	No	No	Unpublished
23	N/D	Male	Persian	3.60	0.80	Localized	No	Splenomegaly	Unpublished
24	N/D	Female	Afghan	3.60	1.25	Disseminated	No	Splenomegaly, Lung involvement	Unpublished

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ISSN: 1476-0711

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