Population snapshot of the extended-spectrum β-lactamase-producing Escherichia coli invasive strains isolated from a Hungarian hospital

Table 2 Resistome and plasmid replicons of the ESBL-producing ExPEC strains

Isolate		Ec1	Ec2	Ec3	Ec4	Ec5	Ec6
β-lactams	blaCTX-M-15	+	+	+
	blaCTX-M-27				+	+	+
	blaTEM-1B		+
Fluoroquinolones	gyrA* (S83L)	+	+	+	+	+	+
	gyrA* (D87N)	+	+	+	+	+	+
	parC* (S80I)	+	+	+	+	+	+
	parC* (E84V)	+	+	+	+	+
	parE* (I529L)	+	+	+	+	+
	parE* (L416F)						+
	qnrB19^‡	+	+	+
MLS	mph(A)	+		+	+	+	+
MLS	mdf(A)	+	+	+	+	+	+
Sulphonamide	sul1	+	+	+	+	+	+
Sulphonamide	sul2	+	+	+	+	+	+
Tetracyclines	tet(A)	+	+	+	+	+	+
Trimethoprim	dfrA17	+		+	+	+	+
Trimethoprim	dfrA1		+
Aminoglycosides	ant(3'')-Ia		+	+
	aadA1		+
	aadA5	+		+	+	+	+
	aph(3'')-Ib	+	+	+	+	+	+
	aph(6)-Id	+	+	+	+	+	+
	aac(3)-IIa	+	+	+
Plasmid replicon types		IncFIB IncFIA IncFII Col156 Col(pHAD28)	IncFIB IncFII IncQ1 Col8282 Col(pHAD28)	IncFIB IncFIA IncFII Col156 Col(pHAD28)	IncFIB IncFIA IncFII Col156 Col8282 Col(pHAD28	IncFIB IncFIA IncFII	IncFIB IncFIA IncFII Col156 Col(BS512)

Acquired antibiotic resistance genes, resistance related point mutations of the isolates. The Ec1, Ec2, Ec3 correspond to ST131 C2/H30Rx isolates, Ec4, Ec5 correspond to ST131 C1-M27 isolates and Ec6 corresponds to ST1193. The + indicates the presence of a gene, *the mutations in quinolone resistance determining region, and ^‡the plasmid-mediated quinolone resistance

ISSN: 1476-0711