Table 2 Ciprofloxacin number of doses used, minimum inhibitory concentration (MICs) and mechanisms of fluoroquinolone resistance detected among 18 Enterobacteriaceae strains isolated from 16 men undergoing transrectal ultrasound-guided prostate biopsy
Isolate no | Species | Date of isolation | Antibiotic-course treatment and number of doses | MIC CIP (mg/L) | Mutation(s) | PMQRs | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GyrA | GyrB | ParC | ParE | ||||||||||
9 I | E. coli | 4.12.2015 | 1 × Cip | 0.25 | – | – | M605L | – | – | – | – | – | qnrS1 |
10 I | E. coli | 11.12.2015 | 1 × Cip | 0.25 | S83L | – | – | – | – | – | – | – | qnrS1 |
40 | E. coli | 25.03.2016 | 1 × Cip | 0.25 | – | – | – | – | – | – | V461E | – | qnrS1 |
41 | E. coli | 25.03.2016 | 1 × Cip | 0.5 | S83L | – | – | S80R | – | – | – | – | – |
10 II | E. cloaceae | 11.12.2015 | 1 × Cip | 2 | S83F | – | – | – | – | – | – | A512T | qnrS1 |
6 | E. coli | 4.12.2015 | 5 × Cip | 6 | S83L | D87N | – | S80I | – | – | – | – | – |
11 | E. coli | 11.12.2015 | 3 × Cip | 8 | S83L | D87N | – | S80I | – | – | – | – | – |
14 | E. coli | 15.01.2016 | 5 × Cip | 8 | S83L | – | – | – | E84G | – | – | – | qnrS1 |
42 | E. coli | 25.03.2016 | 2 × Cip | 8 | S83L | D87N | – | S80I | – | – | – | – | – |
18 I | E. coli | 23.01.2016 | 1 × Cip | 12 | S83L | D87N | – | S80I | – | – | – | – | – |
34 I | E. coli | 11.03.2016 | 12 × Cip | 12 | S83L | D87N | – | S80I | – | – | – | – | qnrS |
20 | E. coli | 5.02.2016 | 1 × Cip | 24 | S83L | D87N | – | S80I | – | – | – | – | – |
38 | E. coli | 18.03.2016 | 2 × Cip | 24 | S83L | D87N | – | S80I | – | – | – | – | – |
33 | E. coli | 11.03.2016 | 4 × Cip | 32 | S83L | D87N | – | S80I | – | – | – | – | qnrS1 |
12 | E. coli | 11.12.2015 | 3 × Cip | > 32 | S83L | D87N | – | S80I | E84M | – | – | – | – |
28 | E. coli | 4.03.2016 | 3 × Cip | > 32 | S83L | D87N | – | S80I | E84V | – | – | – | qnrS |
34 II | E. coli | 11.03.2016 | 12 × Cip | > 32 | S83L | D87N | – | S80I | – | S458A | – | – | – |
43 | E. coli | 25.03.2016 | 10 × Cip | > 32 | S83L | D87N | – | S80R | E84K | – | – | – | qnrS2 |