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Table 2 Ciprofloxacin number of doses used, minimum inhibitory concentration (MICs) and mechanisms of fluoroquinolone resistance detected among 18 Enterobacteriaceae strains isolated from 16 men undergoing transrectal ultrasound-guided prostate biopsy

From: The molecular mechanisms of fluoroquinolone resistance found in rectal swab isolates of Enterobacterales from men undergoing a transrectal prostate biopsy: the rationale for targeted prophylaxis

Isolate no Species Date of isolation Antibiotic-course treatment and number of doses MIC CIP (mg/L) Mutation(s) PMQRs
GyrA GyrB ParC ParE
9 I E. coli 4.12.2015 1 × Cip 0.25 M605L qnrS1
10 I E. coli 11.12.2015 1 × Cip 0.25 S83L qnrS1
40 E. coli 25.03.2016 1 × Cip 0.25 V461E qnrS1
41 E. coli 25.03.2016 1 × Cip 0.5 S83L S80R
10 II E. cloaceae 11.12.2015 1 × Cip 2 S83F A512T qnrS1
6 E. coli 4.12.2015 5 × Cip 6 S83L D87N S80I
11 E. coli 11.12.2015 3 × Cip 8 S83L D87N S80I
14 E. coli 15.01.2016 5 × Cip 8 S83L E84G qnrS1
42 E. coli 25.03.2016 2 × Cip 8 S83L D87N S80I
18 I E. coli 23.01.2016 1 × Cip 12 S83L D87N S80I
34 I E. coli 11.03.2016 12 × Cip 12 S83L D87N S80I qnrS
20 E. coli 5.02.2016 1 × Cip 24 S83L D87N S80I
38 E. coli 18.03.2016 2 × Cip 24 S83L D87N S80I
33 E. coli 11.03.2016 4 × Cip 32 S83L D87N S80I qnrS1
12 E. coli 11.12.2015 3 × Cip  > 32 S83L D87N S80I E84M
28 E. coli 4.03.2016 3 × Cip  > 32 S83L D87N S80I E84V qnrS
34 II E. coli 11.03.2016 12 × Cip  > 32 S83L D87N S80I S458A
43 E. coli 25.03.2016 10 × Cip  > 32 S83L D87N S80R E84K qnrS2
  1. Cip ciprofloxacin