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Table 2 Single amino acid polymorphisms related to antimicrobial resistance in 14 colistin-resistant OXA-48-producing K. pneumoniae strains

From: Comparative genome analysis of colistin-resistant OXA-48-producing Klebsiella pneumoniae clinical strains isolated from two Iranian hospitals

Protein Strains
Cephalosporin resistance Elfamycin resistance Fosfomycin resistance Repressor of multi-drug resistance operon Fluoroquinolone resistance Colistin resistance
PBP3 EF-Tu UhpT MarR ParC GyrA GyrB PhoP PhoQ PmrA PmrB MgrB RamA AcrB CrrB
P6 D350N, S357N R234F E350Q S3N S80I S83I E466D Intact D150G Intact R256G Intact D71B Intact Intact
P7 D350N, S357N R234F E350Q S3N S80I S83I E466D Intact D150G Intact R256G Intact D71B Intact A200E
P26 D350N, S357N R234F E350Q S3N S80I S83I E466D Intact D150G Intact R256G Intact D71B Intact Intact
P31 D350N, S357N R234F E350Q Intact S80I S83I Intact Intact D150G Intact R256G Intact Intact Intact Intact
P32 D350N, S357N R234F E350Q E86K S80I S83I Intact Intact D150G Intact R256G Insertion of ISKpn72 Intact Intact Intact
P33 D350N, S357N R234F E350Q E86K S80I S83I Intact Intact D150G Intact R256G C28W Intact Intact Intact
P35 D350N, S357N R234F E350Q Intact S80I S83F Intact Intact Intact A41T Intact Stop codon (Q30*) Intact Intact Intact
P36 D350N, S357N R234F E350Q E86K S80I S83I Intact Intact D150G Intact R256G Intact Intact Intact Intact
P37 D350N, S357N R234F E350Q E86K S80I D87N Intact Intact D150G A218V Intact Deletion Intact Intact ND
P38 D350N, S357N R234F E350Q Intact P403A S83F Intact Intact Intact A41T Intact Stop codon (Q30*) Intact Intact Intact
P40 D350N, S357N R234F E350Q E86K S80I S83I Intact Intact D150G Intact R256G Intact Intact Intact Intact
P42 D350N, S357N R234F E350Q E86K S80I S83I Intact Intact D150G Intact R256G C28W Intact Intact Intact
P43 D350N, S357N R234F E350Q E86K S80I D87G E466D Intact D150G Intact R256G Intact I25T Intact Intact
P44 D350N, S357N R234F E350Q E86K S80I S83I Intact Intact D150G Intact R256G Intact intact Intact Intact
  1. ND means not detected