Table.6 Combination effect of SBD and VAN on MRSA
Compound | Concentration (μg/mL) | FIC index | Sum FIC index | Interaction | Static/cidal effect | ||
|---|---|---|---|---|---|---|---|
SBD | VAN | SBD | VAN | ||||
SBD2 | 8 | 4 | 1.00 | 1.00 | 2.00 | Additive | Bacteriostatic |
4 | 4 | 0.50 | 1.00 | 1.50 | Additive | Bacteriostatic | |
2 | 4 | 0.25 | 1.00 | 1.25 | Additive | Bacteriostatic | |
1 | 4 | 0.13 | 1.00 | 1.13 | Additive | Bacteriostatic | |
0.5 | 4 | 0.06 | 1.00 | 1.06 | Additive | Bacteriostatic | |
8 | 2 | 1.00 | 0.50 | 1.50 | Additive | Bacteriostatic | |
4 | 2 | 0.50 | 0.50 | 1.00 | Additive | Bacteriostatic | |
2 | 2 | 0.25 | 0.50 | 0.75 | Additive | Bacteriostatic | |
1 | 2 | 0.13 | 0.50 | 0.63 | Additive | Bacteriostatic | |
0.5 | 2 | 0.06 | 0.50 | 0.56 | Additive | Bacteriostatic | |
8 | 1 | 1.00 | 0.25 | 1.25 | Additive | Bacteriostatic | |
4 | 1 | 0.50 | 0.25 | 0.75 | Additive | Bacteriostatic | |
2 | 1 | 0.25 | 0.25 | 0.50 | Synergy | Bacteriostatic | |
1 | 1 | 0.13 | 0.25 | 0.38 | Synergy | Bacteriostatic | |
0.5 | 1 | 0.06 | 0.25 | 0.31 | Synergy | Bacteriostatic | |
8 | 0.5 | 1.00 | 0.13 | 1.13 | Additive | Bacteriostatic | |
8 | 0.25 | 1.00 | 0.06 | 1.06 | Additive | Bacteriostatic | |
SBD4 | 32 | 4 | 1.00 | 1.00 | 2.00 | Additive | Bactericidal |
16 | 4 | 0.50 | 1.00 | 1.50 | Additive | Bacteriostatic | |
8 | 4 | 0.25 | 1.00 | 1.25 | Additive | Bacteriostatic | |
4 | 4 | 0.13 | 1.00 | 1.13 | Additive | Bacteriostatic | |
2 | 4 | 0.06 | 1.00 | 1.06 | Additive | Bacteriostatic | |
32 | 2 | 1.00 | 0.50 | 1.50 | Additive | Bacteriostatic | |
16 | 2 | 0.50 | 0.50 | 1.00 | Additive | Bacteriostatic | |
8 | 2 | 0.25 | 0.50 | 0.75 | Additive | Bacteriostatic | |
4 | 2 | 0.13 | 0.50 | 0.63 | Additive | Bacteriostatic | |
2 | 2 | 0.06 | 0.50 | 0.56 | Additive | Bacteriostatic | |
32 | 1 | 1.00 | 0.25 | 1.25 | Additive | Bacteriostatic | |
16 | 1 | 0.50 | 0.25 | 0.75 | Additive | Bacteriostatic | |
32 | 0.5 | 1.00 | 0.13 | 1.13 | Additive | Bacteriostatic | |
16 | 0.5 | 0.50 | 0.13 | 0.63 | Additive | Bacteriostatic | |
8 | 0.5 | 0.25 | 0.13 | 0.38 | Synergy | Bacteriostatic | |
32 | 0.25 | 1.00 | 0.06 | 1.06 | Additive | Bacteriostatic | |
16 | 0.25 | 0.50 | 0.06 | 0.56 | Additive | Bacteriostatic | |