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Table 3 Concordance of genotypic and phenotypic resistance in blaCTX-M-harbouring Escherichia coli

From: Molecular detection of blaCTX-M gene to predict phenotypic cephalosporin resistance and clinical outcome of Escherichia coli bloodstream infections in Vietnam

Antibiotic substanceb blaCTX-M, n = 80a blaCTX-M-positive ESBL-producers, n = 58a blaCTX-M-positive non ESBL producers, n = 22a
S I R S I R S I R
n % n % n % n % n % n % n % n % n %
AM 0 0 80 100 0 0 58 100 0 0 22 100
AMC 48 60 9 11.3 23 28.8 40 69 9 15.5 9 15.5 8 36.4 0 14 63.6
TZP 64 80 9 11.3 7 8.8 51 87.9 6 10.3 1 1.7 13 59.1 3 13.6 6 27.3
CAZ 35 43.8 1 1.3 44 55 27 46.6 1 1.7 30 51.7 8 36.4 0 14 63.6
CTX 11 13.8 0 69 86.3 0 0 58 100 11 50 0 11 50
FEPc 37 50 10 13.5 27 36.5 29 55.8 8 15.4 15 28.8 8 36.4 2 9.1 12 54.5
ETP 77 96.3 2 2.5 1 1.3 57 98.3 1 1.7 0 20 90.9 1 4.5 1 4.5
IPM 80 100 0 0 58 100 0 0 22 100 0 0
MEM 80 100 0 0 58 100 0 0 22 100 0 0
AN 78 97.5 1 1.3 1 1.3 58 100 0 0 20 90.9 1 4.5 1 4.5
GM 52 65 3 3.8 25 31.3 39 67.2 1 1.7 18 31 13 59.1 2 9.1 7 31.8
CIP 18 22.5 1 1.3 61 76.3 14 24.1 1 1.7 43 74.1 4 18.2 0 18 81.8
  1. AMC: Amoxicillin/Clavulanic acid; TZP: Piperacillin/Tazobactam; ESBL: extended spectrum beta lactamase; CTX: Cefotaxime; CAZ: Ceftazidime; FEP: Cefepime; AN: Amikacin; CIP: Ciprofloxacin; S: susceptible; I: intermediate; R: resistant
  2. aMay not add up to 100% due to rounding errors to 1 decimal place
  3. bInterpretation of resistance according to the clinical breakpoints of CLSI
  4. c6 missing values for cefepime