Table 2 Minimal inhibitory concentration, virulence and resistance-associated genes identified by whole genome sequence
Isolate Year MLST | Beta-Lactams’ resistance genes | Aztreonam (MIC) | Meropenem (MIC) | Imipenem (MIC) | Ceftazidime (MIC) | DD Ceftazidime Avibactam | Aminoglycosides resistance genes | Amikacin (MIC) | Colistin (MIC) | Tigecycline (MIC) | Quinolone resistance genes | Ciprofloxacin (MIC) | Virulence genes adherence | Virulence gene efflux pump | Virulence gene iron acquisition |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
K. pneumoniae (1411) 10/19/2012 ST340 | blaCTX-M-15 blaKPC-2 blaSHV-11 blaTEM-1B | ≥ 32 [R] | ≥ 16 [R] | ≥ 16 [R] | ≥ 16 [R] | 25 mm [S] | aac (3)-Iia aac(6′)Ib-cr aadA2 strA strB | < 4 [S] | 4 | 0.5 | aac (6')Ib-cr oqxA oqxB QnrB1 | ≥ 4 [R] | mrkA/B/C/D/F/H/I/J filmA/B/C/D/E/F/G/H/I/K | acrA/B | iutA entA/B/C/D/E/F/S fepA/B/C/D/G iroE/N |
K. pneumoniae (1581) 12/14/2012 ST340 | blaKPC-2 blaSHV-11 | ≥ 32 [R] | 4 [R] | 2 | 16 [R] | 24 mm [S] | aph (3′)-Ia aadA2 | 8 | ≥ 4 [R] | 0.5 | oqxA oqxB | ≥ 4 [R] | mrkC/H/I/J filmA/B/D/E/G/H/I | acrA/B | entA/B/C fepB/G iroN |
K. pneumoniae (4301) 10/16/2014 ST340 | blaKPC-2 blaSHV-5 blaSRT-2 | ≥ 32 [R] | ≥ 16 [R] | ≥ 16 [R] | ≥ 16 [R] | 30 mm [S] | Aph(3′)-Via | 16 | 0,5 | 0.5 | OqxA oqxB fosA dfrA14 | ≥ 4 [R] | mrkA/B/C/D/F/H/I/J filmA/B/C/D/E/F/G/H/I/K | acrA/B | iutA entA/B/C/D/E/F/S fepA/B/C/D/G iroE/N |
S. marcescens (1756) 6/14/2013 | blaKPC-2 blaSHV-5 blaSRT-2 | ≥ 32 [R] | 4 [R] | 8 | ≥ 16 [R] | 24 mm [S] | aacA4 aac(6′)-Ic aadB | 16 | ≥ 4 [R] | 2 | aac(6′)-Ib-cr | ≥ 4 [R] | shlA/B rssA/B | ||
K. pneumoniae (4990) 10/21/16 ST258 | blaCTX-M-14 blaKPC-2 blaSHV-11 blaTEM-1B | ≥ 32 [R] | ≥ 64[R] | ≥ 16 [R] | ≥ 16 [R] | 23 mm [S] | rmtB aac(3)-Iid aph(3′)-Ia aadA2 aph(6)-Id aph(3′′)-Ib | ≥ 64 [R] | 2 | 0.5 | oqxA oqxB | ≥ 4 [R] | mrkA/B/C/D/F/H/I/J filmA/B/C/D/E/F/G/H/I/K | acrA/B | iutA entA/B/C/D/E/F/S fepA/B/C/D/G iroE/N |