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Table 1 Performance of GenoType MTBDRsl v.2.0 assays compared Phenotypic DST in detecting resistance to FQs, SLIDs, and XDR-TB

From: Direct detection of resistance to fluoroquinolones/SLIDs in sputum specimen by GenoType MTBDRsl v.2.0 assay A study from Eastern Uttar Pradesh, India

GenoType MTBDRsl v.2.0

Assay

 

FQs

 

Phenotypic DST

 

Resistant

Susceptible

Total

Sensitivity = 100%

Resistant

186

1

187

Specificity = 92.3%

Susceptible

0

38

38

NPV = 100%

Total

186

39

225

PPV = 98.41%

  

SLIDs

 
 

Resistant

Susceptible

Total

Sensitivity = 100%

Resistant

48

0

48

Specificity = 100%

Susceptible

0

177

177

NPV = 100%

Total

48

177

225

PPV = 100%

   

XDR-TB

 

GenoType MTBDRsl v.2.0

Assay

  

Phenotypic DST

 
 

Resistant

Susceptible

Total

Sensitivity = 100%

Resistant

48

0

48

Specificity = 100%

Susceptible

0

177

177

NPV = 100%

Total

48

177

225

PPV = 100%

  1. NPV = negative predictive value; PPV = positive predictive value, CI = 95%