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Table 1 Collected data related to the use of antibiotics in COVID-19 (up to July 5, 2020)

From: Repurposing of antibiotics for clinical management of COVID-19: a narrative review

Authors name + reference

Antibiotics

Types of study

Potential viral targets and/or other properties

IC50 inhibition or posology

Pani et al. [82]

Azithromycin

Review

Anti-inflammatory and immunomodulatory effects

Not indicated

Choudhary et al. [83]

Azithromycin

Review

Membrane fusion inhibition

Not indicated

Gautret et al. [26]

Azithromycin

Non-randomized clinical trial

Membrane fusion inhibition

500 mg on the first day then 250 mg/day for 5 more days

Andreani et al. [32]

Azithromycin

In vitro

Membrane fusion inhibition

10 and 5 μM

Touret et al. [84]

Azithromycin, levofloxacin

In vitro

Membrane fusion inhibition and replication inhibition

Not indicated

Ceccarelli et al. [42]

Teicoplanin

Letter to the editor

Interaction between viral spike protein and ACE2 receptors inhibition

6 mg/kg every 24 h

Baron et al. [41]

Teicoplanin

Editorial

Interaction between viral spike protein and ACE2 receptors inhibition

Not indicated

Zhang et al. [43]

Teicoplanin

Original article

Interaction between viral spike protein and ACE2 receptors inhibition

1.66 µΜ

Sathyamoorthy et al. [85]

Teicoplanin

Letter to the editor

Interaction between viral spike protein and ACE2 receptors inhibition

Not indicated

He and Garmire [86]

COL-3 (a chemically modified tetracycline)

Computational study

Interaction between viral spike protein and ACE2 receptors inhibition

Not indicated

Sodhi and Etminan [87]

Tetracyclines

Letter to the editor

Zinc‐chelating and anti-inflammatory effects

Not indicated

Wang [58]

Eravacycline, streptomycin

Computational study

Replication inhibition

Not indicated

Conforti et al. [88]

Doxycycline

Letter to the editor

Anti-inflammatory effect

Not indicated

Farouk and Salman [89]

Doxycycline

Letter to the editor

Anti-inflammatory effect

Not indicated

Malek et al. [90]

Doxycycline

Editorial

Anti-inflammatory effect

Not indicated

Szolnoky [91]

Doxycycline

Letter to the editor

Anti-inflammatory effect

Not indicated

Sargiacomo et al. [52]

Doxycycline, azithromycine

Research perspective

Protein synthesis, viral replication inhibition

Not indicated

Bonzano et al. [92]

Doxycycline

Opinion

Protein synthesis, viral replication inhibition, and immunomodulatory effect

Not indicated

Karampela and Dalamaga [64]

Levofloxacin, moxifloxacin

Opinion

Immunomodulatory effect

Not indicated

Marciniec et al. [65]

Ciprofloxacin, moxifloxacin

In silico study

Viral replication inhibition

Not indicated

Durojaiye et al. [81]

Cefuroxime

In silico study

Interaction between viral spike protein and ACE2 receptors and viral replication inhibition

Not indicated

Chalichem et al. [73]

Aminoglycosides

 

Membrane fusion inhibition

Not indicated