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Table 1 Collected data related to the use of antibiotics in COVID-19 (up to July 5, 2020)

From: Repurposing of antibiotics for clinical management of COVID-19: a narrative review

Authors name + reference Antibiotics Types of study Potential viral targets and/or other properties IC50 inhibition or posology
Pani et al. [82] Azithromycin Review Anti-inflammatory and immunomodulatory effects Not indicated
Choudhary et al. [83] Azithromycin Review Membrane fusion inhibition Not indicated
Gautret et al. [26] Azithromycin Non-randomized clinical trial Membrane fusion inhibition 500 mg on the first day then 250 mg/day for 5 more days
Andreani et al. [32] Azithromycin In vitro Membrane fusion inhibition 10 and 5 μM
Touret et al. [84] Azithromycin, levofloxacin In vitro Membrane fusion inhibition and replication inhibition Not indicated
Ceccarelli et al. [42] Teicoplanin Letter to the editor Interaction between viral spike protein and ACE2 receptors inhibition 6 mg/kg every 24 h
Baron et al. [41] Teicoplanin Editorial Interaction between viral spike protein and ACE2 receptors inhibition Not indicated
Zhang et al. [43] Teicoplanin Original article Interaction between viral spike protein and ACE2 receptors inhibition 1.66 µΜ
Sathyamoorthy et al. [85] Teicoplanin Letter to the editor Interaction between viral spike protein and ACE2 receptors inhibition Not indicated
He and Garmire [86] COL-3 (a chemically modified tetracycline) Computational study Interaction between viral spike protein and ACE2 receptors inhibition Not indicated
Sodhi and Etminan [87] Tetracyclines Letter to the editor Zinc‐chelating and anti-inflammatory effects Not indicated
Wang [58] Eravacycline, streptomycin Computational study Replication inhibition Not indicated
Conforti et al. [88] Doxycycline Letter to the editor Anti-inflammatory effect Not indicated
Farouk and Salman [89] Doxycycline Letter to the editor Anti-inflammatory effect Not indicated
Malek et al. [90] Doxycycline Editorial Anti-inflammatory effect Not indicated
Szolnoky [91] Doxycycline Letter to the editor Anti-inflammatory effect Not indicated
Sargiacomo et al. [52] Doxycycline, azithromycine Research perspective Protein synthesis, viral replication inhibition Not indicated
Bonzano et al. [92] Doxycycline Opinion Protein synthesis, viral replication inhibition, and immunomodulatory effect Not indicated
Karampela and Dalamaga [64] Levofloxacin, moxifloxacin Opinion Immunomodulatory effect Not indicated
Marciniec et al. [65] Ciprofloxacin, moxifloxacin In silico study Viral replication inhibition Not indicated
Durojaiye et al. [81] Cefuroxime In silico study Interaction between viral spike protein and ACE2 receptors and viral replication inhibition Not indicated
Chalichem et al. [73] Aminoglycosides   Membrane fusion inhibition Not indicated