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Table 4 Multivariable Cox regression analysis for 393 Candida bloodstream infection episodes

From: Epidemiology, species distribution, and outcome of nosocomial Candida spp. bloodstream infection in Shanghai: an 11-year retrospective analysis in a tertiary care hospital

 

Survival

(n = 281)

28-day outcome

Multivariable analysis

Death

(n = 112)

P-value

HR (95%CI)

P-value

Male

216(76.9)

76(67.9)

0.065

-

-

Age, years

55.2(19.5)

63.6(16.2)

 < 0.01

1.025(1.013–1.037)

 < 0.001

Underlying disease

   

-

-

Solid tumor

91(32.4)

27(24.1)

0.106

-

-

Hematologic malignancy

32(11.4)

16(14.3)

0.428

-

-

Diabetes mellitus

49(17.4)

28(25)

0.088

-

-

Chronic Cardiac disease

72(25.6)

52(46.4)

 < 0.01

-

0.105

Chronic Pulmonary disease

34(12.1)

18(16.1)

0.294

-

-

Chronic renal failure

20(7.1)

22(19.6)

 < 0.01

2.018(1.234–3.299)

0.005

Skin barrier compromised

24(8.5)

2(1.8)

0.015

-

0.308

Prior surgical intervention (< 1 month)

182(64.8)

62(55.4)

0.083

-

-

Corticosteroid use

40(14.2)

14(12.5)

0.652

-

-

Prior antifungal agents use (< 6 month)

64(22.8)

24(21.4)

0.772

-

-

Severity of clinical feature

   

-

-

Fever (T > 38.2℃)

220(78.3)

89(79.5)

0.798

-

-

Parenteral nutrition

124(44.1)

56(50)

0.292

-

-

Mechanical ventilation

89(31.7)

58(51.8)

 < 0.01

1.950(1.307–2.912)

0.001

Renal replacement therapy

32(11.4)

17(15.2)

0.305

-

-

Central venous catheter

227(80.8)

89(79.5)

0.766

-

-

Severe neutropenia

24(8.5)

18(16.1)

0.029

4.347(2.462–7.675)

 < 0.001

Antifungal therapy

224(74.9)

75(25.1)

0.007

0.502(0.294–0.857)

0.006

No treatment

57(60.6)

37(39.4)

  1. Data were expressed as mean ± SD for continuous variables and n (%) for categorical variables
  2. SD standard deviation