| Survival (n = 281) | 28-day outcome | Multivariable analysis | |||
---|---|---|---|---|---|---|
Death (n = 112) | P-value | HR (95%CI) | P-value | |||
Male | 216(76.9) | 76(67.9) | 0.065 | - | - | |
Age, years | 55.2(19.5) | 63.6(16.2) |  < 0.01 | 1.025(1.013–1.037) |  < 0.001 | |
Underlying disease | Â | Â | Â | - | - | |
Solid tumor | 91(32.4) | 27(24.1) | 0.106 | - | - | |
Hematologic malignancy | 32(11.4) | 16(14.3) | 0.428 | - | - | |
Diabetes mellitus | 49(17.4) | 28(25) | 0.088 | - | - | |
Chronic Cardiac disease | 72(25.6) | 52(46.4) |  < 0.01 | - | 0.105 | |
Chronic Pulmonary disease | 34(12.1) | 18(16.1) | 0.294 | - | - | |
Chronic renal failure | 20(7.1) | 22(19.6) |  < 0.01 | 2.018(1.234–3.299) | 0.005 | |
Skin barrier compromised | 24(8.5) | 2(1.8) | 0.015 | - | 0.308 | |
Prior surgical intervention (< 1 month) | 182(64.8) | 62(55.4) | 0.083 | - | - | |
Corticosteroid use | 40(14.2) | 14(12.5) | 0.652 | - | - | |
Prior antifungal agents use (< 6 month) | 64(22.8) | 24(21.4) | 0.772 | - | - | |
Severity of clinical feature | Â | Â | Â | - | - | |
Fever (T > 38.2℃) | 220(78.3) | 89(79.5) | 0.798 | - | - | |
Parenteral nutrition | 124(44.1) | 56(50) | 0.292 | - | - | |
Mechanical ventilation | 89(31.7) | 58(51.8) |  < 0.01 | 1.950(1.307–2.912) | 0.001 | |
Renal replacement therapy | 32(11.4) | 17(15.2) | 0.305 | - | - | |
Central venous catheter | 227(80.8) | 89(79.5) | 0.766 | - | - | |
Severe neutropenia | 24(8.5) | 18(16.1) | 0.029 | 4.347(2.462–7.675) |  < 0.001 | |
Antifungal therapy | 224(74.9) | 75(25.1) | 0.007 | 0.502(0.294–0.857) | 0.006 | |
No treatment | 57(60.6) | 37(39.4) |