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Table 5 Features of the colistin-resistant isolates

From: Molecular characteristics of antibiotic-resistant Escherichia coli and Klebsiella pneumoniae strains isolated from hospitalized patients in Tehran, Iran

Strain

mRNA relative fold change (mean_SD)

 

MIC Colistin

pmrA

pmrB

pmrC

pmrK

phoP

phoQ

mgrB

pmrA

pmrB

phoP

phoQ

K37

8/586 ± 0/8623

5/098 ± 0/1077

7/672 ± 0/4285

17/00 ± 0/1000

14/20 ± 1/100

9/283 ± 0/1431

Insertional inactivation, IS5-like element at nt 75

WT

WT

E57 D

WT

128

K38

3/991 ± 1/01,882

3/338 ± 0/3023

3/921 ± 0/1005

14/07 ± 0/04,619

10/07 ± 0/05,196

6/100 ± 0/110

WT

WT

WT

WT

WT

64

K50

4/022 ± 1/2985

4/040 ± 0/1600

3/215 ± 0/09,500

14/00 ± 0/02,887

10/01 ± 0/09,000

5/913 ± 0/02,309

c88t (non-sense, premature termination)

WT

WT

WT

WT

64

K52

1/390 ± 0/06,399

2/090 ± 0/1100

1/100 ± 0/1000

3/933 ± 0/05,774

3/077 ± 0/13,959

2/833 ± 0/05,774

WT

WT

WT

WT

WT

4

K53

1/803 ± 0/4468

2/130 ± 0/1000

0/9667 ± 0/3055

3/927 ± 0/06,429

3/117 ± 0/08,432

2/890 ± 0/1645

WT

WT

WT

WT

WT

4

K54

2/459 ± 0/4448

3/755 ± 0/1750

3/161 ± 0/1489

8/288 ± 0/1324

8/070 ± 0/1127

3/657 ± 0/4841

WT

WT

WT

WT

WT

16

K57

1/423 ± 0/3998

2/105 ± 0/2250

1/100 ± 0/2200

3/993 ± 0/1007

3/114 ± 0/1114

2/863 ± 0/1095

WT

WT

WT

WT

WT

4

K83

7/200 ± 0/5196

4/907 ± 0/08,388

6/950 ± 0/2500

15/03 ± 0/1155

12/31 ± 0/01,732

6/427 ± 0/3719

c88t (non-sense, premature

termination)

WT

WT

WT

D150 G

128

K101

8/068 ± 0/1746

4/463 ± 0/2728

8/800 ± 1/700

15/17 ± 0/1155

15/02 ± 0/1921

8/202 ± 0/02,250

c88t (non-sense, premature termination)

WT

T157 P

WT

WT

128

K111

1/341 ± 0/3346

2/010 ± 0/09,000

0/9650 ± 1/0650

4/100 ± 0/010

2/657 ± 0/16,773

2/737 ± 0/1097

WT

WT

WT

WT

WT

4

K130

3/419 ± 0/1695

3/265 ± 0/06,500

1/750 ± 0/4500

6/173 ± 0/04,619

5/212 ± 0/09,789

3/227 ± 0/32,011

c88t (non-sense, premature termination)

WT

WT

WT

WT

8

K134

2/410 ± 0/3100

1/891 ± 0/07,106

1/165 ± 1/06,500

4/033 ± 0/15,774

4/083 ± 0/44,849

3/097 ± 0/1052

WT

WT

WT

WT

WT

4

K136

3/403 ± 0/4935

3/251 ± 0/1506

1/610 ± 0/4900

6/867 ± 0/1528

6/119 ± 0/09,812

3/795 ± 0/009,104

C117a (non-sense, premature termination)

WT

WT

WT

WT

8

K148

2/017 ± 0/2170

1/618 ± 0/5824

0/9343 ± 0/2152

3/980 ± 0/13,464

2/354 ± 0/25,048

2/173 ± 1/06,429

WT

WT

WT

WT

WT

4

K151

1/210 ± 0/2707

1/570 ± 0/1300

1/010 ± 0/2722

3/977 ± 0/14,041

2/387 ± 0/1024

2/137 ± 1/06,429

WT

WT

WT

WT

WT

4

K158

2/082 ± 0/1729

1/801 ± 0/2206

1/043 ± 0/1429

2/173 ± 0/14,619

2/357 ± 1/04,518

2/143 ± 0/1097

WT

WT

WT

WT

WT

4

  1. K. pneumoniae ATCC 700603 served as a quality control
  2. WT wild type, nt nucleotide