Strain | mRNA relative fold change (mean_SD) | Â | MIC Colistin | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
pmrA | pmrB | pmrC | pmrK | phoP | phoQ | mgrB | pmrA | pmrB | phoP | phoQ | ||
K37 | 8/586 ± 0/8623 | 5/098 ± 0/1077 | 7/672 ± 0/4285 | 17/00 ± 0/1000 | 14/20 ± 1/100 | 9/283 ± 0/1431 | Insertional inactivation, IS5-like element at nt 75 | WT | WT | E57 D | WT | 128 |
K38 | 3/991 ± 1/01,882 | 3/338 ± 0/3023 | 3/921 ± 0/1005 | 14/07 ± 0/04,619 | 10/07 ± 0/05,196 | 6/100 ± 0/110 | WT | WT | WT | WT | WT | 64 |
K50 | 4/022 ± 1/2985 | 4/040 ± 0/1600 | 3/215 ± 0/09,500 | 14/00 ± 0/02,887 | 10/01 ± 0/09,000 | 5/913 ± 0/02,309 | c88t (non-sense, premature termination) | WT | WT | WT | WT | 64 |
K52 | 1/390 ± 0/06,399 | 2/090 ± 0/1100 | 1/100 ± 0/1000 | 3/933 ± 0/05,774 | 3/077 ± 0/13,959 | 2/833 ± 0/05,774 | WT | WT | WT | WT | WT | 4 |
K53 | 1/803 ± 0/4468 | 2/130 ± 0/1000 | 0/9667 ± 0/3055 | 3/927 ± 0/06,429 | 3/117 ± 0/08,432 | 2/890 ± 0/1645 | WT | WT | WT | WT | WT | 4 |
K54 | 2/459 ± 0/4448 | 3/755 ± 0/1750 | 3/161 ± 0/1489 | 8/288 ± 0/1324 | 8/070 ± 0/1127 | 3/657 ± 0/4841 | WT | WT | WT | WT | WT | 16 |
K57 | 1/423 ± 0/3998 | 2/105 ± 0/2250 | 1/100 ± 0/2200 | 3/993 ± 0/1007 | 3/114 ± 0/1114 | 2/863 ± 0/1095 | WT | WT | WT | WT | WT | 4 |
K83 | 7/200 ± 0/5196 | 4/907 ± 0/08,388 | 6/950 ± 0/2500 | 15/03 ± 0/1155 | 12/31 ± 0/01,732 | 6/427 ± 0/3719 | c88t (non-sense, premature termination) | WT | WT | WT | D150 G | 128 |
K101 | 8/068 ± 0/1746 | 4/463 ± 0/2728 | 8/800 ± 1/700 | 15/17 ± 0/1155 | 15/02 ± 0/1921 | 8/202 ± 0/02,250 | c88t (non-sense, premature termination) | WT | T157 P | WT | WT | 128 |
K111 | 1/341 ± 0/3346 | 2/010 ± 0/09,000 | 0/9650 ± 1/0650 | 4/100 ± 0/010 | 2/657 ± 0/16,773 | 2/737 ± 0/1097 | WT | WT | WT | WT | WT | 4 |
K130 | 3/419 ± 0/1695 | 3/265 ± 0/06,500 | 1/750 ± 0/4500 | 6/173 ± 0/04,619 | 5/212 ± 0/09,789 | 3/227 ± 0/32,011 | c88t (non-sense, premature termination) | WT | WT | WT | WT | 8 |
K134 | 2/410 ± 0/3100 | 1/891 ± 0/07,106 | 1/165 ± 1/06,500 | 4/033 ± 0/15,774 | 4/083 ± 0/44,849 | 3/097 ± 0/1052 | WT | WT | WT | WT | WT | 4 |
K136 | 3/403 ± 0/4935 | 3/251 ± 0/1506 | 1/610 ± 0/4900 | 6/867 ± 0/1528 | 6/119 ± 0/09,812 | 3/795 ± 0/009,104 | C117a (non-sense, premature termination) | WT | WT | WT | WT | 8 |
K148 | 2/017 ± 0/2170 | 1/618 ± 0/5824 | 0/9343 ± 0/2152 | 3/980 ± 0/13,464 | 2/354 ± 0/25,048 | 2/173 ± 1/06,429 | WT | WT | WT | WT | WT | 4 |
K151 | 1/210 ± 0/2707 | 1/570 ± 0/1300 | 1/010 ± 0/2722 | 3/977 ± 0/14,041 | 2/387 ± 0/1024 | 2/137 ± 1/06,429 | WT | WT | WT | WT | WT | 4 |
K158 | 2/082 ± 0/1729 | 1/801 ± 0/2206 | 1/043 ± 0/1429 | 2/173 ± 0/14,619 | 2/357 ± 1/04,518 | 2/143 ± 0/1097 | WT | WT | WT | WT | WT | 4 |