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Table 3 Clinical adverse effects of study drugs in children

From: Efficacy and safety of azithromycin and amoxicillin/clavulanate for otitis media in children: a systematic review and meta-analysis of randomized controlled trials

Author (year) Azithromycin group Amox-clav group P-Value
Daniel (1993) 7.77% 3.7% N/A
Schaad (1993) 11.7% 22.4%  < 0.002
Principi (1995) 4.5% 8.3% 0.0146
Arguedas et al. (1996) 17.% 66.7% N/A
Gerson (1996) 3.5% 31%  < 0.001
Mohini (1996) 7.2% 17.11%  < 0.001
Samuel (1996) 8.8% 32.64%  < 0.0001
Dagan (2000) 21.7% 27.12% 0.327
Arrieta et al. (2003) 31.8% 42.07% 0.095
Block et al. (2003) 16.8% 22.54% NS
Dune et al. (2003) 11.2% 20% 0.014
Hoberman et al. (2005) 35.3% 37.9% NS
Guven et al. (2006) 4.4% 4.76% NS
Arguedas et al. (2011) 45.6% 64.16% N/A