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Table 3 Clinical adverse effects of study drugs in children

From: Efficacy and safety of azithromycin and amoxicillin/clavulanate for otitis media in children: a systematic review and meta-analysis of randomized controlled trials

Author (year)

Azithromycin group

Amox-clav group

P-Value

Daniel (1993)

7.77%

3.7%

N/A

Schaad (1993)

11.7%

22.4%

 < 0.002

Principi (1995)

4.5%

8.3%

0.0146

Arguedas et al. (1996)

17.%

66.7%

N/A

Gerson (1996)

3.5%

31%

 < 0.001

Mohini (1996)

7.2%

17.11%

 < 0.001

Samuel (1996)

8.8%

32.64%

 < 0.0001

Dagan (2000)

21.7%

27.12%

0.327

Arrieta et al. (2003)

31.8%

42.07%

0.095

Block et al. (2003)

16.8%

22.54%

NS

Dune et al. (2003)

11.2%

20%

0.014

Hoberman et al. (2005)

35.3%

37.9%

NS

Guven et al. (2006)

4.4%

4.76%

NS

Arguedas et al. (2011)

45.6%

64.16%

N/A