Table 1 Review of H. canis human infections case reports

Burnens et al. [7]

Male, 

5 years

NR

NR

Gastroenteritis

Stool: Rotavirus, H. canis

NR

Gerrard et al. [8]

Male, 27 years

X-linked hypogammaglobulinemia

Dog

Recurrent fever, bilateral cellulitis

Blood culture: H. canis, F. rapinni

Doxycycline and metronidazole p.o. 5 months

Leemann et al. [9]

Male, 44 years

Immunocompetent

Dog, cats

Multifocal cellulitis, subfebrile

Blood culture: H. canis

Ceftriaxone 2 g daily i.v. 2 weeks

Prag et al. [10]

Female, 7 months

Immunocompetent

Cat

Acrocyanosis, intermittent fever

Blood culture: H. canis

Ampicillin and gentamicin i.v. followed by mecillinam p.o. 10 days

Alon et al. [11]

Male, 78 years

Diffuse large B cell lymphoma (R-CHOP)

Dogs

Subfebrile episodes,

paroxysmal AF

Blood culture: H. canis

H. pylori eradication regimen

Tankovic et al. [12]

Female, 52 years

Crohn’s disease (mesalazine)

Cat

Epigastralgia

Duodenal biopsy: H. canis

Not treated

Abidi et al. [13]

Female, 57 years

CVID, pulmonary sarcoidosis (prednisone), splenectomy

Dogs, cats

Recurrent fever, chills, and sweats for 3 months

Blood culture: H. canis

Ceftriaxone 2 g daily i.v. 2 weeks, doxycycline 100 mg p.o. 6 weeks

Van der Vusse et al. [14]

Female, 41 years

Kidney transplant (tacrolimus, prednisone, mycophenolate mofetil)

Dog

Fever and cough

Blood culture: H. canis

Cefuroxime 1.5 g 3 times daily i.v. 3 days followed by ciprofloxacin 500 mg p.o. 10 days

Shakir et al. [5]

Male, 49 years

Immunocompetent

Dogs, cats

Cellulitis

Blood culture: H. canis

One dose of vancomycin 1.5 g i.v., doxycycline 100 mg twice daily p.o. 5 days, amoxicillin/clavulanic acid 500 mg daily p.o. 8 weeks

Gutiérrez-Arroyo et al. [15]

Male, 2 months

NR

NR

Cardiorespiratory arrest

Blood culture: H. canis

Death