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Table 1 Review of H. canis human infections case reports

From: Helicobacter canis bacteraemia in a rheumatoid arthritis patient treated with tofacitinib: case report and literature review

Author [reference] Gender, age Immune system competency Pet contact Clinical presentation Detection Treatment
Burnens et al. [7] Male, 
5 years
NR NR Gastroenteritis Stool: Rotavirus, H. canis NR
Gerrard et al. [8] Male, 27 years X-linked hypogammaglobulinemia Dog Recurrent fever, bilateral cellulitis Blood culture: H. canis, F. rapinni Doxycycline and metronidazole p.o. 5 months
Leemann et al. [9] Male, 44 years Immunocompetent Dog, cats Multifocal cellulitis, subfebrile Blood culture: H. canis Ceftriaxone 2 g daily i.v. 2 weeks
Prag et al. [10] Female, 7 months Immunocompetent Cat Acrocyanosis, intermittent fever Blood culture: H. canis Ampicillin and gentamicin i.v. followed by mecillinam p.o. 10 days
Alon et al. [11] Male, 78 years Diffuse large B cell lymphoma (R-CHOP) Dogs Subfebrile episodes,
paroxysmal AF
Blood culture: H. canis H. pylori eradication regimen
Tankovic et al. [12] Female, 52 years Crohn’s disease (mesalazine) Cat Epigastralgia Duodenal biopsy: H. canis Not treated
Abidi et al. [13] Female, 57 years CVID, pulmonary sarcoidosis (prednisone), splenectomy Dogs, cats Recurrent fever, chills, and sweats for 3 months Blood culture: H. canis Ceftriaxone 2 g daily i.v. 2 weeks, doxycycline 100 mg p.o. 6 weeks
Van der Vusse et al. [14] Female, 41 years Kidney transplant (tacrolimus, prednisone, mycophenolate mofetil) Dog Fever and cough Blood culture: H. canis Cefuroxime 1.5 g 3 times daily i.v. 3 days followed by ciprofloxacin 500 mg p.o. 10 days
Shakir et al. [5] Male, 49 years Immunocompetent Dogs, cats Cellulitis Blood culture: H. canis One dose of vancomycin 1.5 g i.v., doxycycline 100 mg twice daily p.o. 5 days, amoxicillin/clavulanic acid 500 mg daily p.o. 8 weeks
Gutiérrez-Arroyo et al. [15] Male, 2 months NR NR Cardiorespiratory arrest Blood culture: H. canis Death
  1. H Helicobacter; F Flexispira; NR not reported; p.o. per os; i.v. intravenous; R-CHOP rituximab-cyclophosphamide, hydroxydaunorubicin hydrochloride (doxorubicin), oncovin (vincristine), prednisone; AF atrial fibrillation; CVID common variable immunodeficiency