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Table 2 ETEST performance based on FDA guidance

From: Contemporary analysis of ETEST for antibiotic susceptibility and minimum inhibitory concentration agreement against Pseudomonas aeruginosa from patients with cystic fibrosis

Antibiotic

EA (%)

CA (%)

VME* No. (%)

ME* No. (%)

miE* No. (%)

Recalculated miE** No. (%)

ATM

78

87

0

2 (3.3%)

13 (12.4%)

5 (4.8%)

FEP

72

64

0

5 (9.4%)

33 (31.4%)

13 (12.4%)

CAZ

82

91

1 (4.2%)

0

9 (8.6%)

3 (2.9%)

CZA

78

93

2 (18.2%)/0 (0.0%)*

5 (5.3%)/2 (2.1%)*

ND

ND

C/T

86

93

0

1 (1.4%)

6 (5.7%)

1 (1.0%)

CIP

79

8

0

0

16 (15.2%)

5 (4.8%)

LVX

63

83

0

0

18 (17.1%)

8 (7.6%)

MEM

86

91

0

2 (3.3%)

7 (6.7%)

3 (2.9%)

TZP

77

85

0

2 (2.9%)

14 (13.3%)

11 (10.5%)

TOB

82

81

0

1 (1.5%)

19 (18.1%)

6 (5.7%)

  1. EA: essential agreement; CA: categorical agreement; VME: very major error; ME: major error; miE: minor error; ND: not done
  2. *FDA thresholds for VME, ≤ 2%; ME, < 3%; no criteria for miE; VME and ME thresholds based on adjusted analysis (excluding EA) for CZA due to absence of intermediate breakpoint
  3. **Recalculated minor errors (excluding EA)