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Table 4 Initial antibiotics selected based on PCGS versus those that would have been chosen under the Japanese guidelines

From: Point-of-care cerebrospinal fluid Gram stain for the management of acute meningitis in adults: a retrospective observational study

  Point-of-care Gram stain (N = 34) Japanese guidelines (N = 34) p value
GPC (N = 23) GNR (N = 8) False-negative (N = 3) Total Immunocompetent Immunocompromised (N = 17) Total  
Age < 50 (N = 7) Age≥50 (N = 10)
Ampicillin/Penicillin G 10/1 4/0 1/0 16 0 5/0 8/0 13 0.62
Cefotaxime/Ceftriaxone 17/6 5/1 3/0 32 0 3/2 0 5  < 0.001*
Ceftazidime 0 1 0 1 0 0 8 8 0.027*
Vancomycin 18 1 2 21 0 10 17 27 0.18
Meropenem 0 1 0 1 7 5 7 19  < 0.001*
Clindamycin 0 1 0 1 0 0 0 0 1.000
  1. GNR Gram-negative rod, GPC Gram-positive coccus, PCGS point-of-care Gram stain
  2. *p < 0.05