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Table 4 Initial antibiotics selected based on PCGS versus those that would have been chosen under the Japanese guidelines

From: Point-of-care cerebrospinal fluid Gram stain for the management of acute meningitis in adults: a retrospective observational study

 

Point-of-care Gram stain (N = 34)

Japanese guidelines (N = 34)

p value

GPC (N = 23)

GNR (N = 8)

False-negative (N = 3)

Total

Immunocompetent

Immunocompromised (N = 17)

Total

 

Age < 50 (N = 7)

Age≥50 (N = 10)

Ampicillin/Penicillin G

10/1

4/0

1/0

16

0

5/0

8/0

13

0.62

Cefotaxime/Ceftriaxone

17/6

5/1

3/0

32

0

3/2

0

5

 < 0.001*

Ceftazidime

0

1

0

1

0

0

8

8

0.027*

Vancomycin

18

1

2

21

0

10

17

27

0.18

Meropenem

0

1

0

1

7

5

7

19

 < 0.001*

Clindamycin

0

1

0

1

0

0

0

0

1.000

  1. GNR Gram-negative rod, GPC Gram-positive coccus, PCGS point-of-care Gram stain
  2. *p < 0.05