Table 3 The most commonly studied characteristics as predictors of mortality in the reviewed studies
Risk factor | ESBL-PE only studies n/N (%) | ESBL-PE vs non- ESBL-PE studies n/N (%) | Total n/N (%) | Identified as independent predictor for mortality |
|---|---|---|---|---|
Age | 5/6 (83.3) | 13/19 (68.4) | 18/25 (72.0) | 0 + 0 |
Gender | 4/6 (66.7) | 11/19 (57.9) | 15/25 (60.0) | 0 + 1 (22) |
CCI | 1/6 (16.7) | 4/19 (21.1) | 5/25 (20.0) | 0 + 2 (16,42) |
ESBL production | 1/6 (16.7) | 12/19 (63.2) | 13/25 (52.0) | 0 + 3 (13,14,16) |
Neutropenia | 2/6 (33.3) | 11/19 (57.9) | 13/25 (52.0) | 0 + 4 (13,14,24,35) |
Inadequate initial antimicrobial treatment | 3/6 (50.0) | 13/19 (68.4) | 16/25 (64.0) | 0 + 3 (13,19,25) |
ICU admission | 2/6 (33.3) | 6/19 (31.6) | 8/25 (32.0) | 0 + 5 (14,19,27,33,34) |
Immunosuppressant use | 0 | 3/19 (15.8) | 3/25 (12.0) | 0 + 1 (14) |
Indwelling urinary catheter | 2/6 (33.3) | 1/19 (5.3) | 3/25 (12.0) | 1 (23) + 1 (14) |
Infecting organism, Klebsiella pneumoniae | 0 | 5/19 (26.3) | 5/25 (20.0) | 0 + 1 (18) |
Intra-abdominal infection | 4/6 (66.7) | 3/19 (15.8) | 7/25 (28.0) | 0 + 1 (28) |
Mechanical ventilation | 0 | 2/19 (10.5) | 2/25 (8.0) | 0 + 1 (16) |
Metastasis | 0 | 1/19 (5.3) | 1/25 (4.0) | 0 + 1 (33) |
Organ failure | 1/6 (16.7) | 2/19 (10.5) | 3/25 (12.0) | 0 + 1 (33) |
Pneumonia | 1/6 (16.7) | 5/19 (26.3) | 6/25 (24.0) | 1 (31) + 4 (14,16,21,28) |
Pitt bacteremia score | 4/6 (66.7) | 4/19 (21.1) | 8/25 (32.0) | 1 (32) + 2 (14,42) |
Severe sepsis/ septic shock | 3/6 (50.0) | 11/19 (57.9) | 14/25 (56.0) | 1 (31) + 8 (14,16,18,19,22,24,28,33) |
Solid tumor | 3/6 (50.0) | 8/19 (42.1) | 11/25 (44.0) | 0 + 1 (27) |
Simultaneous corticosteroid therapy | 0 | 8/19 (42.1) | 8/25 (32.0) | 0 + 2 (19,27) |