|
Therapy
|
MO
|
Median (IQR) % live cells
|
Median (IQR) % reduction of live cells
|
P value
|
Median (IQR) log10 cfu/ml*
|
Median (IQR) % reduction** of cfu/ml*
|
P value
|
|---|
|
C+
|
ALT
|
C+
|
ALT
|
|---|
|
Treatment
|
P. aeruginosa
|
88.9 (84.4–93.4)
|
39.3 (30.1–50.9)
|
53.2 (39.4–64.1)
|
< 0.001
|
7.5 (7.4– b)
|
-a
|
100.0 (100.0–100.0)
|
0.002
|
|
E. coli
|
55.9 (49.6–67.3)
|
18.8 (12.5–31.2)
|
67.9 (46.7–78.7)
|
0.002
|
7.0 (6.7–7.4)
|
-a
|
100.0 (100.0–100.0)
|
0.002
|
|
S. aureus
|
42.9 (28.7–57.5)
|
0.0 (0.0–0.0)
|
100.0 (100.0–100.0)
|
0.007
|
7.7 (7.5–7.9)
|
-a
|
100.0 (100.0–100.0)
|
0.002
|
|
Prophylaxis
|
P. aeruginosa
|
83.1 (77–88.4)
|
0.0 (0.0–0.0)
|
100.0 (100.0–100.0)
|
< 0.001
|
7.4 (6.9–8.4)
|
-a
|
**Absence
|
0.004
|
|
E. coli
|
43.9 (34.1–46.1)
|
0.0 (0.0–0.0)
|
100.0 (100.0–100.0)
|
<0.001
|
7.2 (6.9–7.34)
|
-a
|
**Absence
|
0.002
|
|
S. aureus
|
32.7 (23.7–49.7)
|
0.0 (0.0–0.0)
|
100.0 (100.0–100.0)
|
0.008
|
7.6 (7.4–7.8)
|
-a
|
**Absence
|
0.002
|
- P values were obtained using Mann–Whitney U test
- MO microorganism, IQR interquartile range, cfu colony forming units, C + positive control, ALT antibiotic lock therapy
- aNo cells were recovered after therapy. Cfu/ml resulted to be 0 (0.0-0.0) for all microorganisms after every therapy being log10 of 0 in-calculated
- bNo p75 value obtained
- *Limit of detection of cfu counting using conventional culture was 10 cfu/ml
- **In prophylaxis therapy, no reduction could be measured, as there was no pre-formed biofilm. Results are expressed as absence
