Skip to main content

Table 1 Overall data of live cells, cfu/ml counts, and percentage of reduction of bacterial biofilms after prophylaxis and treatment with selective digestive decontamination solution

From: Selective digestive decontamination solution used as “lock therapy” prevents and eradicates bacterial biofilm in an in vitro bench-top model

Therapy MO Median (IQR)  % live cells Median (IQR)  % reduction of live cells P value Median (IQR) log10 cfu/ml* Median (IQR)  % reduction** of cfu/ml* P value
C+ ALT C+ ALT
Treatment P. aeruginosa 88.9 (84.4–93.4) 39.3 (30.1–50.9) 53.2 (39.4–64.1) < 0.001 7.5 (7.4– b) -a 100.0 (100.0–100.0) 0.002
E. coli 55.9 (49.6–67.3) 18.8 (12.5–31.2) 67.9 (46.7–78.7) 0.002 7.0 (6.7–7.4) -a 100.0 (100.0–100.0) 0.002
S. aureus 42.9 (28.7–57.5) 0.0 (0.0–0.0) 100.0 (100.0–100.0) 0.007 7.7 (7.5–7.9) -a 100.0 (100.0–100.0) 0.002
Prophylaxis P. aeruginosa 83.1 (77–88.4) 0.0 (0.0–0.0) 100.0 (100.0–100.0) < 0.001 7.4 (6.9–8.4) -a **Absence 0.004
E. coli 43.9 (34.1–46.1) 0.0 (0.0–0.0) 100.0 (100.0–100.0) <0.001 7.2 (6.9–7.34) -a **Absence 0.002
S. aureus 32.7 (23.7–49.7) 0.0 (0.0–0.0) 100.0 (100.0–100.0) 0.008 7.6 (7.4–7.8) -a **Absence 0.002
  1. P values were obtained using Mann–Whitney U test
  2. MO microorganism, IQR interquartile range, cfu colony forming units, C +  positive control, ALT antibiotic lock therapy
  3. aNo cells were recovered after therapy. Cfu/ml resulted to be 0 (0.0-0.0) for all microorganisms after every therapy being log10 of 0 in-calculated
  4. bNo p75 value obtained
  5. *Limit of detection of cfu counting using conventional culture was 10 cfu/ml
  6. **In prophylaxis therapy, no reduction could be measured, as there was no pre-formed biofilm. Results are expressed as absence