Fig. 7
Antibacterial efficacy of CAP in a rat model. On the back of 24 rats, two excision wounds were inoculated with 107 CFU PAO1 for 24 h. During 7 days, the wounds received a single CAP treatment (data not shown), repeated treatments on 4 consecutive days with CAP, 100 µL of 1% (wt/wt) silver sulfadiazine or no treatment. The bacterial load of the wounds was determined using daily swabs (a) or punch biopsies after euthanasia of rats on day 3 and day 7 (b). Results are expressed as the number of surviving bacteria in log10 (CFU/swab or biopt). Data represent the means of at least five samples. Statistical differences compared to CFU from swabs before treatment (Wilcoxon S-R) or biopsies of untreated wounds (MWU) are indicated: *p < 0.05; **p < 0.01; ***p < 0.001