Table 1 Main features of reported cases of human infections caused by N. takedensis
From: Nocardia takedensis: a newly recognized pathogen responsible for skin and soft tissue infections
Authors | Sex/age (years) | Underlying conditions(s) | Immunosuppression (risk factors) | Type of infection | Treatment | Inoculation | Geographical origin of the strain | Methods of identification | Evolution |
|---|---|---|---|---|---|---|---|---|---|
Watanabe et al. [2] | M/75 | T-lymphoma | Yes (T-lymphoma) | NA | NA | NA | Japan | Sequencing 16S rRNA gene | NA |
Betran et al. [13] | F/41 | Diabetes Eosinophilic granuloma | Yes (corticosteroid, diabetes) | Lung colonization | NA | NA | Spain | Sequencing 16S rRNA gene | NA |
Tan et al. [5] | F/68 | Diabetes Chronic kidney disease | Yes (diabetes, chronic kidney disease) | Foot cellulitis | Trimethoprim-Sulfamethoxazole | Unknown | Taiwan | Sequencing 16S rRNA gene | Recovery |
Kresch-Tronik et al. [4] | M/33 | NA | NA | Thoracic mycetoma | Trimethoprim-Sulfamethoxazole (800/160 mg/b.i.d) and Dapsone (100 mg/day)—14 months | Local traumatic injury | Mexico | Sequencing 16S rRNA gene | Recovery |
Chung et al. [3] | F/68 | Follicular lymphoma Myelodysplastic syndrome | Yes (corticosteroid, immunosuppressive treatment with sirolimus) | Lymphangitis of the left forearm | Cefuroxime (500 mg/b.i.d)—7 days Amoxicillin-clavulanate (875 mg/b.i.d)—14 days Trimethoprim-Sulfamethoxazole (800/160 mg/b.i.d)—7 days | Abrasion on the left dorsal hand | USA | Sequencing 16S rRNA gene | Recovery |
Coussement et al. [15] | NA | Solid organ transplant | Yes (solid organ transplant) | NA | NA | NA | France | Sequencing 16S rRNA and hsp65 genes | NA |
Geun Lee et al. [6] | F/87 | Arterial hypertension | No | Erythematous and swollen plaque on her left forearm Pustules, abscesses, ulcers | Trimethoprim-Sulfamethoxazole (400/80 mg/b.i.d)—40 days | Abrasion on the left forearm | Korea | Sequencing 16S rRNA gene | Recovery |
Benzaquen et al. [7] | M/76 | Marginal zone lymphoma Diabetes Arterial hypertension | Yes (corticosteroid, immunosuppressive treatment with chloraminophene and rituximab, diabetes) | Chronic ulcerative suppurative and painful nodules on the right forearm | Rifampicin (600 mg/day)—3 months Clarithromycin (500 mg/b.i.d)—6 months Ethambutol (800 mg/day)—6 months | Skin trauma | France | Sequencing 16S rRNA gene | Recovery |
Lebeaux et al. [14] | NA | NA | NA | NA | NA | NA | France | Sequencing 16S rRNA gene | NA |
Patient 1, 2012 (our study) | M/49 | Myeloma | Yes (corticosteroid, immunosuppressive treatment with tacrolimus and lenalidomid) | Skin abscess and ulcerated nodular lymphangitis on the left forearm | Trimethoprim-Sulfamethoxazole—1 month | Skin trauma when gardening | France | Sequencing 16S rRNA gene | Recovery |
Patient 2, 2017 (our study) | M/82 | Myasthenia Diabetes Chronic kidney disease Arterial hypertension | Yes (corticosteroid, immunosuppressive treatment with azathioprin, diabetes, chronic kidney disease) | Skin abscess and nodular lymphangitis on the right forearm | Amoxicillin-clavulanic acid (1 g/t.id)—6 days | Hand skin wound when gardening | France | Sequencing 16S rRNA gene | Recovery |