Table 3 Comparison of the bacterial flora isolated from patients treated with tigecycline before and after the antibiotic stewardship program intervention
Bacteria | Isolated organisms before ASP intervention (N = 374 organisms) (P1) (%) | Isolated organisms after ASP intervention (N = 333 organisms) (P2) (%) | P |
|---|---|---|---|
Gram-negative species | 304 (81.3%) | 296 (88.9%) | 0.005 |
 Escherichia coli | 60 (16%) | 56 (18.8%) | 0.78 |
  3GC S | 14 (3.7%) | 14 (4.2%) | 0.75 |
  3GC R | 46 (12.3%) | 42 (12.6%) | 0.89 |
  CAR S | 60 (16%) | 54 (16.2%) | 0.95 |
  CAR R | 0 | 2 (0.6%) | 0.13 |
 Klebsiella species | 48 (12.8%) | 44 (13.2%) | 0.88 |
  3GC S | 30 (8%) | 13 (3.9%) | 0.02 |
  3GC R | 18 (4.8%) | 31 (9.3%) | 0.02 |
  CAR S | 48 (12.8%) | 31 (9.3%) | 0.14 |
  CAR R | 0 | 13 (3.9%) | < 0.0001 |
 Enterobacter species | 5 (1.3%) | 11 (3.3%) | 0.08 |
 Proteus mirabilis | 19 (5.1%) | 14 (4.2%) | 0.58 |
 Pseudomonas aeruginosa | 45 (12%) | 50 (15%) | 0.25 |
  CAZ S | 34 (9.1%) | 36 (10.8%) | 0.44 |
  CAZ R | 4 (1.1%) | 14 (4.2%) | 0.008 |
  CAZ susceptibility NA | 7 (1.9%) | 0 | – |
  CAR S | 18 (4.8%) | 32 (9.6%) | 0.01 |
  CAR R | 20 (5.4%) | 18 (5.4%) | 0.97 |
  CAR susceptibility NA | 7 (1.9%) | 0 | – |
 Acinetobacter baumannii | 105 (28.1%) | 71 (21.3%) | 0.04 |
  CAR S | 12 (3.2%) | 14 (4.2%) | 0.48 |
  CAR R | 87 (23.3%) | 57 (17.1%) | 0.04 |
  CAR susceptibility NA | 6 (1.6%) | 0 | – |
 Stenotrophomonas maltophilia | 7 (1.9%) | 18 (5.4%) | 0.01 |
Gram-positive species | 70 (18.7%) | 37 (11.1%) | 0.005 |
 Staphylococcus aureus | 11 (2.9%) | 7 (2.1%) | 0.48 |
  MET S | 5 (1.3%) | 5 (1.5%) | 0.76 |
  MET R | 6 (1.6%) | 2 (0.6%) | 0.22 |
 Enterococci | 19 (5.1%) | 11 (3.3%) | 0.24 |
  VAN S | 9 (2.4%) | 8 (2.4%) | 0.99 |
  VAN R | 0 | 3 (0.9%) | 0.07 |