Prevention of cytomegalovirus infection after solid organ transplantation: a Bayesian network analysis

Zhang, Yu; Zhou, Tao; Huang, Mingzhu; Gu, Guangxiang; Xia, Qiang

doi:10.1186/s12941-020-00372-0

Annals of Clinical Microbiology and Antimicrobials

Table 1 Characteristics of the included studies

From: Prevention of cytomegalovirus infection after solid organ transplantation: a Bayesian network analysis

First author	Organ	Prevention strategy	Antiviral drug	Dose (mg/days)	Intervention time (days)	Number of samples	D−/R+ (%)	Follow-up time (days)	Immunosuppressive regimen
Acyclovir vs control
Balfour [6]	Renal	Prophylaxis	Acyclovir	3200	84	53		365	Azathioprine, cyclosporine, prednisone, antiymphoblast globulin
Balfour [6]	Renal	Prophylaxis	Control	3200	84	51		365	Azathioprine, cyclosporine, prednisone, antiymphoblast globulin
Barkholt [7]	Liver	Prophylaxis	Acyclovir	3200	84	28	2 (7)	168	Cyclosporine, azathioprine, steroids
Barkholt [7]	Liver	Prophylaxis	Control	3200	84	27	3 (11)	168	Cyclosporine, azathioprine, steroids
Acyclovir vs ganciclovir
Singh [8]	Liver	Prophylaxis	Acyclovir	3200	7	24	7 (30)	168	Tacrolimus, methylprednisolone
Singh [8]	Liver	Preemptive	Ganciclovir	10 mg/kg	168	23	8 (33)	168	Tacrolimus, methylprednisolone
Duncan [9]	Lung	Prophylaxis	Acyclovir	3200	90	12		742 ± 44	Azathioprine, cyclosporine, antilymphoblast globulin/antilymphocyt globulin, methylprednisolone
Duncan [9]	Lung	Prophylaxis	Ganciclovir	5 mg/kg 5 days/week	90	13		690 ± 85	Azathioprine, cyclosporine, antilymphoblast globulin/antilymphocyt globulin, methylprednisolone
Rubin [10]	Renal, heart, liver	Prophylaxis	Acyclovir	1200	84	78	77 (100)	365
Rubin [10]	Renal, heart, liver	Prophylaxis	Ganciclovir	3000	84	77	78 (100)	365
Winston [11]	Liver	Prophylaxis	Acyclovir	3200	100	109		365	Tacrolimus/cyclosporine, corticosteroids, azathioprine
Winston [11]	Liver	Prophylaxis	Ganciclovir	3000	100	110		365	Tacrolimus/cyclosporine, corticosteroids, azathioprine
Acyclovir vs valacyclovir
Egan [12]	Heart	Prophylaxis	Acyclovir	800	90	13	1 (7)	180	Azathioprine, cyclosporine, prednisolone
Egan [12]	Heart	Prophylaxis	Valacyclovir	2000	90	14	0 (0)	180	Azathioprine, cyclosporine, prednisolone
Ganciclovir vs control
Merigan [13]	Heart	Prophylaxis	Ganciclovir	10 mg/k + 6 mg/kg/days 5 days/week	14 + 14	76	19 (25)	120	Corticosteroids, azathioprine, cyclosporine, OKT3 antibody
Merigan [13]	Heart	Prophylaxis	Control	10 mg/k + 6 mg/kg/days 5 days/week	14 + 14	73	16 (22)	120	Corticosteroids, azathioprine, cyclosporine, OKT3 antibody
Hibberd [14]	Renal	Preemptive	Ganciclovir	2.5 mg/kg/days	9	64		180	Azathioprine, cyclosporine, prednisone, methylprednisolone
Hibberd [14]	Renal	Preemptive	Control	0	0	49		180	Azathioprine, cyclosporine, prednisone, methylprednisolone
Gane [15]	Liver	Prophylaxis	Ganciclovir	3000	98	150	21 (14)	180	Cyclosporine/tacrolimus
Gane [15]	Liver	Prophylaxis	Control	3000	98	154	25 (16)	180	Cyclosporine/tacrolimus
Paya [16]	Liver	Preemptive	Ganciclovir	3000	56	35	9 (26)	110
Paya [16]	Liver	Preemptive	Control	3000	56	34	11 (32)	110
Sagedal [17]	Renal	Preemptive	Ganciclovir	3000	49	42	5 (12)	365	Tacrolimus/cyclosporine, prednisolone
Sagedal [17]	Renal	Deferred	Control	3000	28	38	3 (8)	365	Tacrolimus/cyclosporine, prednisolone
Ganciclovir vs valacyclovir
Pavlopoulou [18]	Renal	Prophylaxis	Ganciclovir	3000	90	40	6 (14)	180	Tacrolimus, MMF, methylprednisolone
Pavlopoulou [18]	Renal	Prophylaxis	Valacyclovir	8000	90	43	6 (15)	180	Tacrolimus, MMF, methylprednisolone
Reischig [19]	Renal	Prophylaxis	Ganciclovir	3000	90	36	5 (14)	730	Tacrolimus, MMF, azathioprine
Reischig [19]	Renal	Prophylaxis	Valacyclovir	8000	90	35	4 (11)	730	Tacrolimus, MMF, azathioprine
Ganciclovir vs valganciclovir
Paya [20]	Heart, liver, renal, pancreas	Prophylaxis	Ganciclovir	3000	100	127	245 (100)	365
Paya [20]	Heart, liver, renal, pancreas	Prophylaxis	Valganciclovir	900	100	245	127 (100)	365
Valganciclovir vs valacyclovir
Reischig [21]	Renal	Prophylaxis	Valganciclovir	900	90	60	7 (11)	365
Reischig [21]	Renal	Prophylaxis	Valacyclovir	8000	90	59	4 (6)	365
Reischig [22]	Renal	Preemptive	Valganciclovir	1800	14	36	6 (16)	1095	Tacrolimus/cyclosporine, MMF
Reischig [22]	Renal	Prophylaxis	Valacyclovir	8000	90	34	4 (12)	1095	Tacrolimus/cyclosporine, MMF

MMF mycophenolate mofetil, OKT3 muromonab-CD3

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ISSN: 1476-0711

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