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Table 1 Characteristics of the included studies

From: Prevention of cytomegalovirus infection after solid organ transplantation: a Bayesian network analysis

First author Organ Prevention strategy Antiviral drug Dose (mg/days) Intervention time (days) Number of samples D−/R+ (%) Follow-up time (days) Immunosuppressive regimen
Acyclovir vs control
 Balfour [6] Renal Prophylaxis Acyclovir 3200 84 53   365 Azathioprine, cyclosporine, prednisone, antiymphoblast globulin
Control 3200 84 51   365 Azathioprine, cyclosporine, prednisone, antiymphoblast globulin
 Barkholt [7] Liver Prophylaxis Acyclovir 3200 84 28 2 (7) 168 Cyclosporine, azathioprine, steroids
Control 3200 84 27 3 (11) 168 Cyclosporine, azathioprine, steroids
Acyclovir vs ganciclovir
 Singh [8] Liver Prophylaxis Acyclovir 3200 7 24 7 (30) 168 Tacrolimus, methylprednisolone
Preemptive Ganciclovir 10 mg/kg 168 23 8 (33) 168 Tacrolimus, methylprednisolone
 Duncan [9] Lung Prophylaxis Acyclovir 3200 90 12   742 ± 44 Azathioprine, cyclosporine, antilymphoblast globulin/antilymphocyt globulin, methylprednisolone
Prophylaxis Ganciclovir 5 mg/kg 5 days/week 90 13   690 ± 85 Azathioprine, cyclosporine, antilymphoblast globulin/antilymphocyt globulin, methylprednisolone
 Rubin [10] Renal, heart, liver Prophylaxis Acyclovir 1200 84 78 77 (100) 365  
Prophylaxis Ganciclovir 3000 84 77 78 (100) 365  
 Winston [11] Liver Prophylaxis Acyclovir 3200 100 109   365 Tacrolimus/cyclosporine, corticosteroids, azathioprine
Prophylaxis Ganciclovir 3000 100 110   365 Tacrolimus/cyclosporine, corticosteroids, azathioprine
Acyclovir vs valacyclovir
 Egan [12] Heart Prophylaxis Acyclovir 800 90 13 1 (7) 180 Azathioprine, cyclosporine, prednisolone
Prophylaxis Valacyclovir 2000 90 14 0 (0) 180 Azathioprine, cyclosporine, prednisolone
Ganciclovir vs control
 Merigan [13] Heart Prophylaxis Ganciclovir 10 mg/k + 6 mg/kg/days 5 days/week 14 + 14 76 19 (25) 120 Corticosteroids, azathioprine, cyclosporine, OKT3 antibody
Prophylaxis Control 10 mg/k + 6 mg/kg/days 5 days/week 14 + 14 73 16 (22) 120 Corticosteroids, azathioprine, cyclosporine, OKT3 antibody
 Hibberd [14] Renal Preemptive Ganciclovir 2.5 mg/kg/days 9 64   180 Azathioprine, cyclosporine, prednisone, methylprednisolone
Preemptive Control 0 0 49   180 Azathioprine, cyclosporine, prednisone, methylprednisolone
 Gane [15] Liver Prophylaxis Ganciclovir 3000 98 150 21 (14) 180 Cyclosporine/tacrolimus
Prophylaxis Control 3000 98 154 25 (16) 180 Cyclosporine/tacrolimus
 Paya [16] Liver Preemptive Ganciclovir 3000 56 35 9 (26) 110  
Preemptive Control 3000 56 34 11 (32) 110  
 Sagedal [17] Renal Preemptive Ganciclovir 3000 49 42 5 (12) 365 Tacrolimus/cyclosporine, prednisolone
Deferred Control 3000 28 38 3 (8) 365 Tacrolimus/cyclosporine, prednisolone
Ganciclovir vs valacyclovir
 Pavlopoulou [18] Renal Prophylaxis Ganciclovir 3000 90 40 6 (14) 180 Tacrolimus, MMF, methylprednisolone
Prophylaxis Valacyclovir 8000 90 43 6 (15) 180 Tacrolimus, MMF, methylprednisolone
 Reischig [19] Renal Prophylaxis Ganciclovir 3000 90 36 5 (14) 730 Tacrolimus, MMF, azathioprine
Prophylaxis Valacyclovir 8000 90 35 4 (11) 730 Tacrolimus, MMF, azathioprine
Ganciclovir vs valganciclovir
 Paya [20] Heart, liver, renal, pancreas Prophylaxis Ganciclovir 3000 100 127 245 (100) 365  
Prophylaxis Valganciclovir 900 100 245 127 (100) 365  
Valganciclovir vs valacyclovir
 Reischig [21] Renal Prophylaxis Valganciclovir 900 90 60 7 (11) 365  
Prophylaxis Valacyclovir 8000 90 59 4 (6) 365  
 Reischig [22] Renal Preemptive Valganciclovir 1800 14 36 6 (16) 1095 Tacrolimus/cyclosporine, MMF
Prophylaxis Valacyclovir 8000 90 34 4 (12) 1095 Tacrolimus/cyclosporine, MMF
  1. MMF mycophenolate mofetil, OKT3 muromonab-CD3