Presence of Borrelia miyamotoi infection in a highly endemic area of Lyme disease

Table 1 Demographics, clinical manifestations and laboratory results on patients with Borrelia miyamotoi PCR positive in the blood

Case	Age	Co-infections	Clinical manifestations	Laboratory findings
Case	Gender	Co-infections	Clinical manifestations	WBC (/mm³)	Hb (g/dL)	Platelets (/mm³)	Creatinine (mg/dL)	AST (IU/L)	ALT (IU/L)
1	90/M	Negative	Fatigue, vomiting, fevers	4100 (90% N)	9.7	91,000	1.46	74	46
2	22/M	Negative	Headaches, fevers, abdominal pain, arthralgia	3200 (88% N)	14.7	99,000	0.8	73	117
3	26/M	Negative	Fevers, diarrhea, hematuria	5400 (40%N, 30%B)	16.3	127,000	1.05	51	68
4	74/M	Negative	Fatigue, arthralgia	4600 (63% N)	14.2	154,000	0.7	21	28
5	32/M	Negative	Fevers, muscle pain, fatigue	3000 (45%N, 9%B)	15.6	166,000	1.0	98	65
6	74/M	Negative	Fevers, myalgia, chills, vomiting	6800 (N37%, B17%)	15.6	51,000	3.1	212	165
7	68/M	Negative	Fever, myalgia, arthralgia, fatigue	Unknown	Unknown	Unknown	Unknown	20	18
8	67/F	Negative	Fevers, arthralgias, mylagias	5500 (N 64%)	14.7	260,000	0.8	33	23
9	60/M	Unknown	Unknown Fevers, arthralgia, myalgias, fatigue	7100 (N 60%)	14.8	Unknown	Unknown	Unknown	Unknown

Case 1–6 were hospitalized. Case 7–9 were diagnosed in the outpatient clinic. All patients received doxycycline 100 mg orally for 14–21 days. Co-infections negative: Babesia, anaplasma and Ehrlichia PCR in blood were negative. Case 1: procalcitonin 0.19 ng/mL. Case 2: CSF analysis showed 14 WBC (86% L), Glucose 69 mg/dL, Protein 22 mg/dL Normal values: WBC (4800–10,800/mm3), Hb (12–16 g/dL), platelets (150,000-450,000/mm3), creatinine (less than 1.2 mg/dL), AST (less than 32 IU/L) and ALT (less than 33 IU/L)
ARF Acute renal failure, CRP C-reactive protein, WBC White blood cells, N Neutrophils, B bands, M monocytes, L Lymphocytes, Hb Hemoglobin, AST aspartate aminotransferase, ALT Alanine aminotransferase

ISSN: 1476-0711