Fig. 5

Photomicrographs of liver; A Normal microscopic view of the organ, with typical hepatic cords (large arrow) and sinusoids (small arrow), and characteristic portal triad showing portal venule (asterisk), hepatic arteriole (black arrowhead) and bile ductula (white arrowheads); B treated by Free SLN: diffuse necrosis and lipoidal degeneration of hepatocyte with foamy cytoplasm, severe sinusoidal congestion (arrowhead) and preportal infiltration of lymphocytes and macrophages (arrow); C untreated: diffuse necrosis and lipoidal degeneration of hepatocyte with foamy cytoplasm, severe sinusoidal congestion (arrowhead) and preportal infiltration of lymphocytes and macrophages (arrow); D treated by DOX-SLN: the normal architecture of liver is being restored with less preportal infiltration of inflammatory cells (arrow) and no sinusoidal congestion; E treated by free doxycycline: Infiltration of white blood cells (arrow) in preportal area and moderate sinusoidal congestion. Hematoxylin & Eosin, Magnification = ×400