IE type | Micro-organism | Reason for surgery | Before-DBV treatment (weeks) | Reasons for DBV prescription | Adverse effects | Cure of infection | DBV dose (mg) | |
---|---|---|---|---|---|---|---|---|
1 | LPVE | MSSA | Yes (1) | 1st. Vancomycin (< 1), and cloxacillin (2); 2nd. surgery; 3rd. cloxacillin (2) plus fosfomycin (2) | Outpatient management | No | Yes | 1000 (1 day) 500 (8 days) |
2 | EPVE | S. epidermidis | Yes (1) | 1st. Daptomycin (< 1) plus rifampicin (< 1); 2nd. vancomycin (2) plus rifampin (2); 3rd. surgery; 4th. vancomycin plus rifampicin (2) | Outpatient management | No | Yes | 1000 (1 day) 500 (8 days) |
3 | EPVE | MRSA | 1st. Vancomycin (< 1); 2nd. daptomycin (3) plus fosfomycin (3) | Outpatient management | Yes (fever) | Yes | 1000 (1 day) 500 (8 days) 500 (15 days) | |
4 | PLE | S. epidermidis | Yes (2) | 1st. Amoxicillin-clavulanic acid (< 1); 2nd. linezolid (3); 3rd. surgery; 4th. daptomycin (4) | Outpatient management | No | Yes | 1500 (1 day) |
5 | NVE | S. agalactiae | Yes (3) | 1st. Vancomycin (< 1); 2nd. penicillin G (3) plus gentamycin (3); 3rd. surgery; 4th. ceftriaxone (1) | Outpatient management | No | Yes | 1500 (1) |
6 | LPVE | S. epidermidis. | 1st. Moxifloxacin (< 1); 2nd. daptomycin (1), cloxacillin (1) plus gentamycin (1), plus rifampicin (1); 3rd. daptomycin (6) | Outpatient management | No | Yes Death not-related with IE (6 months later) | 1000 (1 day) 500 (8 days) | |
7 | NVE | MSSA | 1st. Daptomycin (1) plus gentamycin (1); 2nd. cloxacillin (3) plus gentamycin (1) | Outpatient management | No | Loss to follow up | 1000(1 day) | |
8 | NVE | Unknown | 1st. Ceftriaxone (< 1); 2nd daptomycin (< 1); 3rd. imipenem/cilastatin (1) | Outpatient management | No | Yes | 1500 (1 day) 1000 (15 days) | |
9 | LPVE | S. epidermidis. | 1st. Cloxacillin (< 1) plus daptomycin (< 1); 2nd. daptomycin (3) plus gentamycin (2) plus fosfomycin (2) | Previous treatment failure | No | Yes | 1500 (1 day) | |
10 | PLE | S. epidermidis. | Yes (4) | 1st. Daptomycin (1), gentamycin (1), rifampicin (1), 2nd. surgery | Outpatient management | Yes (renal failure) | Treatment failure | 1500 (1 day) |
11 | NVE | S. agalactiae | 1st. Ertapenem (< 1); 2nd. ampicillin (1) plus gentamycin (1); 3rd. ceftriaxone (1) | Outpatient management | No | Yes | 1500 (1 day) 500 (8 days) | |
12 | NVE | E. faecalis | 1st. Meropenem (< 1); 2nd. ampicillin (3) plus ceftriaxone (3); 3rd. linezolid (1); 4th. daptomycin (2) | Outpatient management | No | Yes | 1000 (1 day) | |
13 | NVE | S. lugdunensis | Yes (1) | 1st. Cloxacillin (3); 2nd. surgery; 3rd daptomycin (1) | Outpatient management | No | Yes | 1500 (1 day) |
14 | EPVE | CNS | Yes (1) | 1st. Aztreonam (< 1); 2nd. daptomycin (2) plus rifampicin (2) plus fosfomycin (2); 3rd. surgery; 4th. daptomycin (2) plus rifampicin (4) plus fosfomycin (4) | Outpatient management | No | Yes | 1500 (1 day) |
15 | LPVE | MSSA | 1st. Piperacillin/tazobactam (1); 2nd. cloxacillin (1) plus daptomycin (1) plus rifampicin (1); 3rd. cloxacillin (2) plus rifampicin (2) plus fosfomycin (< 1) | Outpatient management | No | Yes | 1000 (1 day) | |
16 | NVE | S. viridans | 1st. Amoxicillin-clavulanate (1); 2nd. ceftriaxone (3) | Outpatient management | No | Yes | 1500 (1 day) | |
17 | PLE | S. epidermidis | Yes (4) | 1st. Cloxacillin (< 1) plus gentamycin (< 1) plus rifampicin (1); 2nd. surgery; 3rd. daptomycin (2) | Outpatient management | No | Yes | 1500 (1 day) |
18 | PLE | S. epidermidis | Yes (4) | 1st. Rifampicin (1), gentamycin (1), daptomycin (1); 2nd. surgery | Outpatient management | No | Yes | 1500 (1 day) |
19 | PLE | S. schleiferi | Yes (4) | 1st. Ceftriaxone (< 1); 2nd. surgery; 3rd. cloxacillin (2) | Outpatient management | No | Yes | 1000 (1 day) 500 (8 days) |
20 | PLE | S. epidermidis | Yes (4) | 1st. Meropenem (< 1); 2nd. surgery; 3rd. daptomycin (2) | Outpatient management | No | Yes | 1000 (1 day) |
21 | NVE | MSSA | Yes (1) | 1st. Ceftriaxone (< 1), 2nd. daptomycin (< 1) plus gentamycin (1); 3rd. cloxacillin (1); 4th. Surgery; 5th. cloxacillin (2) plus rifampicin (1) | Outpatient management | No | Yes | 1500 (1 day) |
22 | EPVE | MRSA | Yes (1) | 1st. Daptomycin (2), gentamycin (2), rifampicin (2); 2nd. surgery; 3rd daptomycin (1) | Previous treatment failure | No | Yes | 1500 (1 day) 1000 (15 days) |
23 | NVE | E. faecalis | 1st. Ampicillin plus ceftriaxone (4) | Outpatient management | No | Yes | 1000 (1) 500 (8 days) | |
24 | NVE | MSSA | 1st. Ceftriaxone (< 1) plus levofloxacin (< 1); 2nd. cloxacillin (1); 3rd. cefazolin (1) | Outpatient management | No | Yes Death not-related with IE (3 months later) | 1000 (1 day) | |
25 | PLE | CNS | Yes (5) | 1st. Daptomycin (1), gentamycin (1), rifampicin (1); 2nd. surgery; 3rd. daptomycin (1) | Outpatient management | No | Yes | 1000 (1 day) 5002 (8 days) |
26 | PLE | CNS | Yes (6) | 1st. Levofloxacin (2); 2nd. daptomycin (2); 3rd. surgery; 4th. daptomycin (2) | Outpatient management | No | Yes | 1000 (1 day) 500 (8 days) |
27 | LPVE | MSSA | 1st. Vancomycin (< 1) plus gentamycin (< 1) plus rifampin (< 1), 2nd. daptomycin (1) plus rifampicin (1); 3rd. cloxacillin (2) plus rifampicin (2) | Outpatient management | No | Yes | 1000 (1 day) 500 (8 days) | |
28 | LPVE | MRSA | 1st. Vancomycin (2), 2nd. linezolid (1); 3rd. ceftaroline (4) | Previous treatment failure | No | Yes | 1000 (1 day) 500 mg/every week/9 weeks | |
29 | LPVE | S. bovis | 1st. Vancomycin (< 1) plus rifampicin (< 1) plus gentamycin (< 1), 2nd. ceftriaxone (4) plus gentamycin (4) | Outpatient management | No | Yes Death not-related with IE (4 months later) | 1500 (1 day) 1000/every 2 weeks/10 weeks | |
30 | LPVE | S. lugdunensis | 1st ceftriaxone (< 1); 2nd cloxacillin (2) | Outpatient management | No | Yes | 1000 (1 day) 500 (8 days) | |
31 | NVE | MR S. epidermidis | 1st. Daptomycin (4) | Outpatient management | No | Yes | 1000 (1 day) 500 (8 days) | |
32 | EPVE | MSSA | 1st. Levofloxacin (< 1), 2nd. daptomycin (< 1), 3rd. cloxacillin (4) plus rifampicin (3) plus gentamycin (2) | Outpatient management | No | Yes | 1500 (1 day) | |
33 | LPVE | E. faecalis | Yes (1) | 1st. Vancomycin (2), gentamycin (< 1); 2nd. surgery; 3rd. vancomycin (1) | Outpatient management | No | Yes | 1500 (1 day) 1000 (15 days) 1000 (30 days) 1000 (45 days) |
34 | LPVE | S. epidermidis | Yes (1) | 1st. Daptomycin (2) plus rifampicin (2); 2nd. surgery; 3rd. daptomycin (2) | Outpatient management | No | Yes | 1500 (1 day) |