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Table 2 Previous case reports and series of CSD in immunocompetent children with hepatosplenic abscesses

From: Hepatosplenic abscesses in an immunocompetent child with cat-scratch disease from Peru

#

Type

N

Year of publication

Age (cases) or age-range (series)

Gender

Location

Clinical presentation

Abscess(es)

Treatment

Outcome

Reference

1

Case reports

2

1996

5-year-olda

Male

Houston, TX, USA

Abdominal pain and fever

Hepatosplenic abscesses

Rifampin

Cured

[20]

4-year-olda

Male

Rhinorrhea and fever

Hepatosplenic abscesses

Rifampin

Cured

2

1

1999

7-year-old

Male

Verona, Italy

Regional lymphoadenitis

Hepatosplenic micro-abscesses

Not reported

Cured

[18]

3

1

2003

3-year-old

Female

Phildelphia, PA, USA

Orbital abscess and osteomyelitis

Hepatosplenic abscesses

Ampicillin–sulbactam plus rifampin

Cured

[36]

4

1

2016

16-month-old

Male

Taoyuan, Taiwan

Disseminated

Hepatosplenic micro-abscesses, resolved after 4 months

Azithromycin

Cured

[15]

5

Case series

11

1997

1.5–13 years-old

Male: 12, female: 7

Atlanta, GA, USA

Fever of unknown origin

Splenic: 11, hepatic: 3

Gentamicin, trimethoprim–sulfamethoxazole, rifampin and ciprofloxacin

Cured

[19]

6

 

19

1999

2–8 years-old

Male: 5, female: 6

Houston, TX, USA

Fever and abdominal pain

Hepatosplenic: 13, hepatic: 3, splenic: 3

Gentamicin, rifampin, trimethoprim–sulfamethoxazole, ampicillin

Cured

[37]

 

Current

1

2019

3-year-old

Male

Trujillo, Peru

Persistent fever

Hepatosplenic micro-abscesses

Azithromycin

Cured

 

Total

36

1999–2016

16-month–old to 13 year-old

Male: 22, female: 14

USA: 33, Italy: 1, Taiwan: 1, Peru: 1

Hepatosplenic: 30, hepatic: 6, splenic: 3

Rifampin: 22, trimethoprim–sulfamethoxazole: 13, gentamicin: 10

All cured

  1. aThese are brothers