Table 1 Clinical features and plasma cfDNA levels in patients with severe and non-severe dengue
From: Plasma cell-free DNA: a potential biomarker for early prediction of severe dengue
Characteristics | Non-SD (n = 53) | SD (n = 8) | p-value* |
|---|---|---|---|
Demographic features | |||
 Age—median year (IQR) | 12.0 (10.0–18.0) | 12.5 (10.0–17.3) | 0.9456 |
 Male (%) | 22 (41.5) | 3 (37.5) | 1 |
Clinical symptoms, physical signs and intervention | |||
 Abdominal pain (%) | 30 (56.6) | 6 (75.0) | 0.4525 |
 Persistent vomiting (%) | 4 (7.5) | 2 (25.0) | 0.1731 |
 Mucosal bleeding (%) | 7 (13.2) | 3 (37.5) | 0.1154 |
 Liver enlargement > 2 cm (%) | 1 (1.89) | 1 (12.5) | 0.247 |
 Narrow pulse pressure | 0 | 8 (100) | < 0.0001 |
 Shock manifestation | 0 | 8 (100) | < 0.0001 |
 Infusion (Ringer’s lactate) | 37 (69.8) | 8 (100) | 0.0097 |
Laboratory test | |||
 Secondary infection (%) | 41 (77.36) | 7 (87.5) | 1 |
 PLT (× 103/μL)—median (IQR)a | 123.0 (92.0–165.5) | 101.0 (48.3–147.3) | 0.2784 |
Dengue serotype | |||
 DENV-1 (%) | 9 (17.0) | 1 (12.5) | 1 |
 DENV-2 (%) | 14 (26.4) | 3 (37.5) | 0.674 |
 DENV-3 (%) | 3 (5.7) | 2 (25.0) | 0.1239 |
 DENV-4 (%) | 15 (28.3) | 1 (12.5) | 0.6681 |
 Unknown (%) | 19 (35.8) | 2 (25.0) | 0.7028 |
 Day of sampling from fever onset—median day (IQR) | 3.0 (3.0–4.0) | 3.0 (3.0–4.0) | 0.7368 |
 Time of sampling before defervescence—median hour (IQR) | 20.0 (14.0–28.0) | 15.5 (11.3–23.8) | 0.2931 |
Plasma cfDNA levels, median (IQR), ng/mL | 35.4 (24.4–51.6) | 61.4 (38.3–110.5) | 0.0493 |