Table 2 Clinical and microbiological characteristics of ESBL-producing hvKp isolates
Clinical characteristic | P14 | P32 | P34 | P45 | P51 | P65 | P92 | P133 | P145 | P212 | P221 | P233 | P237 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Age | 86 | 73 | 89 | 90 | 94 | 79 | 85 | 86 | 93 | 91 | 93 | 86 | |
Gender | M | M | M | M | M | M | M | M | M | M | M | M | M |
Clinical department | Cardiology | ICU | Urology | CCU | Respiratory | ICU | Endocrinology | Respiratory | Gastroenterology | ICU | Cardiology | Respiratory | CCU |
Date of specimen (yr/mo/day) | 2011/04/18 | 2010/10/10 | 2010/07/14 | 2008/10/24 | 2008/07/22 | 2010/10/14 | 2011/08/11 | 2011/07/11 | 2013/05/19 | 2014/01/21 | 2013/05/15 | 2013/09/11 | 2013/01/16 |
Main underlying diseases | Cardiovascular diseases | UIP | Prostate Disease | CHD | Bronchiectasis | Diabetes | Diabetes | UIP | Diabetes | UIP | Heart failure | Diabetes | Diabetes |
Tube | CVC; ureter; stomach tube | CVC; ureter; stomach tube; tracheal catheter | CVC; ureter; stomach tube; tracheal catheter | CVC; ureter; stomach tube | Ureter; stomach tube | CVC; ureter; stomach tube; Tracheal catheter | CVC; ureter; stomach tube; tracheal catheter | Non | Non | CVC; ureter; stomach tube; tracheal catheter | CVC; ureter; stomach tube | Stomach tube | Stomach tube |
Specimen type | Sputum | Sputum | Urine | Urine | Sputum | Sputum | Sputum | Sputum | Sputum | Sputum + blood | Urine | Sputum | Sputum |
Infection type | Pneumonia | Sepsis | Sepsis | Urinary infection | Pneumonia | Sepsis | Sepsis | Pneumonia | Pneumonia | Sepsis shock | Urinary infection | Pneumonia | Pneumonia |
WBC (109/L) | 14.36 | 11.35 | 13.14 | 7.33 | 8.34 | 7.38 | 13.2 | 8.47 | 12.26 | 14.1 | 8.3 | 9.45 | 13.3 |
NEU (%) | 82.9 | 87.6 | 81.3 | 69.2 | 67.5 | 66.3 | 83.1 | 70.5 | 78.3 | 64.4 | 69.3 | 81.3 | 76.3 |
TP (g/L) | 67 | 63.7 | 75 | 61 | 58 | 60 | 61 | 69 | 68 | 61 | 64 | 62 | 67 |
ALB (g/L) | 35.2 | 30.7 | 35.7 | 34.5 | 31.3 | 31.5 | 32.9 | 39 | 36.9 | 32.6 | 37.2 | 36.5 | 37.8 |
MDR | Y | Y | Y | Y | Y | Y | Y | N | N | Y | Y | Y | N |
Antibiotic resistance type | Penicillins; cephalosporins; aminoglycosides; beta-lactamase inhibitor; quinolones | Penicillins; cephalosporins; aminoglycosides | Penicillins; cephalosporins; sulfonamides | Penicillins; cephalosporins; aminoglycosides | Penicillins; cephalosporins; aminoglycosides; beta-lactamase inhibitor; quinolones; Sulfonamides | Penicillins; cephalosporins; aminoglycosides; beta-lactamase inhibitor; quinolones; Sulfonamides | Penicillins; cephalosporins; quinolones | Penicillins; cephalosporins; | Penicillins; cephalosporins | Penicillins; cephalosporins; aminoglycosides | Penicillins; cephalosporins; aminoglycosides | Penicillins; cephalosporins; sulfonamides | Penicillins; cephalosporins |
Empiric Therapy | CIP + CAZ | MEM + ISE | CMZ | IPM | MXF | CIP + CAZ | IPM + ISE | MXF | MXF | TZP + ISE | MXF | CIP + CAZ | CIP + CAZ |
Switched Therapy | MEM | MEM | MXF | TZP | MEM | CAZ + TZP | IPM | MXF | MXF | MEM + CIP | MXF | CIP + ISE | CIP + ISE |
SOFA score | 6 | 7 | 10 | 3 | 5 | 7 | 8 | 3 | 5 | 11 | 5 | 7 | 6 |
Clinical outcome | Survived | Survived | Survived | Survived | Survived | Survived | Survived | Survived | Survived | Died | Survived | Survived | Survived |
String test length (mm) | 100 | 30 | 50 | 100 | 40 | 20 | 200 | 45 | 20 | 60 | 8 | 8 | 50 |
Virulence-associated genes | |||||||||||||
rmpA | − | − | − | + | + | + | + | − | + | + | + | − | + |
rmpA2 | − | − | − | + | + | + | + | − | + | + | − | − | + |
magA | + | + | + | + | + | + | + | + | + | + | − | + | + |
aerobactin | + | + | + | + | + | + | + | + | + | + | + | + | + |
cps genes | |||||||||||||
K1 | − | − | − | − | − | − | + | − | − | − | − | − | + |
K2 | − | − | − | − | − | − | − | − | − | − | − | − | − |
K5 | − | − | − | − | − | − | − | − | − | − | − | − | − |
K20 | − | − | − | − | − | − | − | − | − | − | − | − | − |
K54 | − | − | − | − | − | − | − | − | − | − | − | − | − |
K57 | − | − | − | − | − | − | − | − | − | + | − | − | − |
MLST genotyping | 2899 | 2892 | 34 | 2888 | 1264 | 412 | 2898 | 2920 | 23 | 17 | 2836 | 101 | 23 |
Clone complex | Singleton | CC292 | CC34 | CC1 | CC11 | CC412 | CC1 | singleton | CC23 | CC17 | CC292 | CC101 | CC23 |