Table 3 Clinical and bacteriological findings in cases with positive result from either NGS or conventional methods (blood and catheter tip culture)
No. | Age | Sex | BT | Skin redness | Bacteria detected by each method | Final diagnosis | Defervescence time (day) | Antibiotic treatment after the catheter removal | Outcome | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
NGS (the genera or families account for more than 10% of the leads) | Blood culture | Catheter tip culture | Other cultures | |||||||||
CRI suspected group | ||||||||||||
 NGS positive | ||||||||||||
  6 | 76 | F | 36.1 | Yes | Serratia | NA | Serratia marcescens | NA | CRI | – | CMZ | Cure |
  13 | 59 | M | 37.6 | No | Staphylococcus | NA | Negative | NA | SSI | 2 | CPFX | Cure |
  26 | 59 | M | 37.0 | No | Staphylococcus | Negative | Negative | NA | SSI | 1 | FOM | Cure |
  30 | 76 | M | 40.0 | Yes | Staphylococcus | Staphylococcus epidermidis | Staphylococcus epidermidis | NA | CRI | 4 | PIPC/TAZ | Cure |
  92 | 40 | F | 35.9 | No | Enterococcaceae | Negative | Negative | NA | SSI | – | LVFX | Cure |
  107 | 74 | F | 37.0 | No | Enterococcaceae | Negative | Negative | Enterococcus faecalis (drain culture) | SSI | 1 | IPM/CS | Cure |
  114 | 65 | F | 38.7 | No | Staphylococcus, Klebsiella, Enterobacteriaceae | Negative | Klebsiella pneumoniae | NA | CRI | 1 | CEZ | Cure |
  135 | 61 | M | 39.0 | No | Staphylococcus | Staphylococcus aureus | Staphylococcus aureus | NA | CRI | 13 | VCM | Deatha |
  143 | 62 | M | 37.0 | No | Staphylococcus | Negative | Negative | NA | SSI | 1 | LVFX | Cure |
 NGS negative | ||||||||||||
  112 | 62 | M | 37.5 | Yes | Negative | Staphylococcus epidermidis | Negative | NA | CRI | 1 | VCM | Cure |
Routine removal group | ||||||||||||
 NGS positive | ||||||||||||
  31 | 80 | F | 36.4 | No | Staphylococcus | NAb | NA | NA | Post infection (DNAemia) | – | No | – |
  54 | 70 | M | 36.3 | No | Staphylococcus | NA | NA | NA | Contamination | – | No | – |
  88 | 65 | F | 36.6 | No | Staphylococcus | NA | NA | NA | Contamination | – | No | – |
  104 | 82 | F | 35.9 | No | Staphylococcus | NA | NA | NA | Contamination | – | No | – |
  154 | 52 | M | 36.8 | No | Staphylococcus | NA | NA | NA | Contamination | – | No | – |