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TableĀ 1 Clinical diagnosis and Main laboratory results

From: Identification of pathogens in culture-negative infective endocarditis cases by metagenomic analysis

Case no Diagnosis Valve Gram staining Blood culture Valve culture Nanopore NGS Sanger
A1 Definite IEa GPCb Negative Filamentous fungi c S. gordonii S. gordonii S. gordonii
A2 Definite IEa GPCb Negative Negative S. oralis S. oralis S. viridans spp.
A3 Definite IEa Negative Negative Negative Coxiella burnetii Coxiella burnetii Not detected
A4 Definite IEa Negative Negative Negative Bartonella Quintana Bartonella Quintana Bartonella Quintana
A5 Definite IE Negative S. oralis Negative S. oralis S. oralis S. viridans spp.
A6 Definite IEa GPCb Negative Negative S. sanguis S. sanguis S. sanguis
A7 Definite IE GPCb S. anginosus Negative S. anginosus S. anginosus S. anginosus
  1. aDefinite IE was diagnosed according to histopathologic examination, clinical presentation and echocardiographic result
  2. bGPC Gram positive coccus
  3. cThis result was considered to be contamination