Outcome | Number of patients (%) | P value | |
---|---|---|---|
Colistin (n = 61) | Polymyxin B (n = 51) | ||
Nephrotoxicity | 24 (39.3) | 6 (11.8) | 0.001 |
RIFLE | |||
All classes (R+I+F) | 32 (52.4) | 10 (19.6) | < 0.001 |
R | 8 (13.1) | 4 (7.8) | 0.105 |
I | 13 (21.3) | 4 (7.8) | 0.009 |
F | 11 (18.0) | 2 (3.9) | 0.004 |
Secondary outcomes | |||
Need for dialysis | 9 (14.8) | 1 (2.0) | 0.018 |
Need for stopping medication | 9 (14.8) | 1 (2.0) | 0.018 |
Onset of AKI (mean ± SD) | 3.8 ± 0.8 | 4.2 ± 0.7 | 0.373 |
Duration of AKI (mean ± SD) | 4.9 ± 3.1 | 5.0 ± 2.4 | 0.916 |
Reversal of nephrotoxicity, n (%) | 18 (75.0) | 5 (83.3) | 0.666 |