Variable | Colistin (n = 61) | Polymyxin B (n = 51) | P value |
---|---|---|---|
Gender, male | 39 (63.9) | 36 (70.6) | 0.456 |
Age (years) | 64.3 ± 13.3 | 63.4 ± 17.1 | 0.769 |
Weight (kg) | 73.2 ± 11.8 | 69.3 ± 13.4 | 0.106 |
BMI (kg/m2) | 26.8 ± 4.3 | 25.0 ± 4.7 | 0.041 |
APACHE 2 score | 20.8 ± 4.2 | 22.0 ± 4.6 | 0.167 |
Baseline creatinine clearance (ml/min) | 60.8 ± 33.5 | 55.4 ± 31.6 | 0.382 |
DM | 30 (49.2) | 22 (43.1) | 0.523 |
HTN | 12 (19.7) | 11 (21.6) | 0.071 |
Use of vasopressors | 39 (63.9) | 28 (54.9) | 0.381 |
Number of days of antibiotic use [median(IQR)] | 7 (5–7) | 7 (7–9) | 0.221 |
Median daily dose (mg) | 233.3 (150–300) | 200 (180–240) | 0.116 |
Site of infection | |||
Lungs | 28 (45.9) | 38 (74.5) | 0.002 |
Urine | 19 (31.1) | 0 (0) | < 0.001 |
Bloodstream | 5 (8.2) | 5 (9.8) | 0.766 |
Abdomen | 5 (8.2) | 4 (7.8) | 0.945 |
Others | 4 (6.5) | 4 (7.8) | 0.792 |
Pathogens | |||
Klebsiella | 19 (31.1) | 12 (23.5) | 0.370 |
Pseudomonas | 8 (13.1) | 11 (21.6) | 0.235 |
Acinetobacter | 12 (19.7) | 10 (19.6) | 0.993 |
E. coli | 4 (6.5) | 1 (2) | 0.241 |
No growth | 18 (29.5) | 17 (33.3) | 0.664 |