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Table 4 Linear regression models for the incidence density of combined-resistant and carbapenem-resistant P. aeruginosa strains

From: Intensive care antibiotic consumption and resistance patterns: a cross-correlation analysis

Model Multiple R2  (Adj R2) Model p value Coefficients estimate ± StdErr Coefficients p value AIC change p value
1. PsaCR = f(penicillins)
  1.1 PsaCR ~ penicillins 0.766 (0.727) 0.004 Penicillins = 0.040 ± 0.009 0.004  
  1.2 PsaCR ~ penicillins + Penlag-1 0.848 (0.773) 0.023 Penicillins = 0.046 ± 0.01 Penlag-1 = 0.012 ± 0.009 0.012 0.0495
0.255
  1.3 PsaCR ~ penicillins + PsaCRlag-1 0.920 (0.880) 0.006 Penicillins = 0.046 ± 0.01 PsaCRlag-1 = 0.451 ± 0.171 0.004 0.0039
0.058
M 1.4 PsaCR ~ penicillins + PsaCRLlag-1 + Penlag-1 0.953 (0.906) 0.017 Penicillins = 0.047 PsaCRlag-1 = 0.913 ± 0.354 Penlag-1 = − 0.0196 ± 0.013 0.006 0.0066
0.082
0.243
2. PsaCR = f(piperacillin + tazobactam)
M 2.1 PsaCR ~ PipTazo 0.730 (0.686) 0.007 PipTazo = 0.061 ± 0.015 0.007  
  2.2 PsaCR ~ PipTazo + PipTazolag-1 0.743 (0.614) 0.066 PipTazo = 0.063 ± 0.024 PipTazolag-1 = − 0.011 ± 0.037 0.060 0.256
0.783
  2.3 PsaCR ~ PipTazo + PsaCRlag-1 0.776 (0.664) 0.050 PipTazo = 0.070 ± 0.021 PsaCRlag-1 = − 0.32 ± 0.383 0.031 0.132
0.451
  2.4 PsaCR ~ PipTazo + PsaCRlag-1 + PipTazolag-1 0.777 (0.555) 0.166 PipTazo = 0.069 ± 0.027 PsaCRlag-1 = − 0.352 ± 0.517 PipTazolag-1 = 0.006 ± 0.047 0.087 0.862
0.545
0.911
3. PsaCARB = f(carbapenems)
M 3.1 PsaCARB ~ carbapenems 0.861 (0.838) < 0.001 Carbapenems = 0.046 ± 0.008 < 0.001  
  3.2 PsaCARB ~ carbapenems + Carblag-1 0.899 (0.848) 0.010 Carbapenems = 0.046 ± 0.008 Carblag-1 = 0.013 ± 0.01 0.005 0.256
0.266
  3.3 PsaCARB ~ carbapenems + PsaCARBlag-1 0.893 (0.839) 0.012 Carbapenems = 0.046 ± 0.009 PsaCARBlag-1 = 0.242 ± 0.208 0.006 0.203
0.310
  3.4 PsaCARB ~ carbapenems + PsaCARBlag-1 + Carblag-1 0.899 (0.798) 0.053 Carbapenems = 0.046 ± 0.009 PsaCARBlag-1 = 0.051 ± 0.495 Carblag-1 = 0.010 ± 0.024 0.018 0.975
0.925
0.692
4. PsaCARB = f(meropenem)
  4.1 PsaCARB ~ meropenem 0.733 (0.689) 0.0076 Meropenem = 0.046 ± 0.011 0.007  
  4.2 PsaCARB ~ meropenem + Merolag-1 0.794 (0.691) 0.043 Meropenem = 0.039 ± 0.016 Merolag-1 = 0.020 ± 0.018 0.071 0.130
0.330
  4.3 PsaCARB ~ meropenem + PsaCARBlag-1 0.738 (0.607) 0.069 Meropenem = 0.052 ± 0.017 PsaCARBlag-1 = − 0.117 ± 0.37 0.037 0.435
0.765
M 4.3 PsaCARB ~ meropenem + PsaCARBlag-1 + Merolag-1 0.921 (0.842) 0.037 Meropenem = 0.041 ± 0.011 PsaCARBlag-1 = − 0.709 ± 0.32 Merolag-1 = 0.047 ± 0.018 0.038 0.030
0.116
0.078
  1. M—best model, selected based on the overall statistical significance, multiple R2 (Adjusted R2), and Akaike information criterion. For each outcome incidence density model, the first *.1 is the initial model to which additional variables were subsequently added; the Chi square test was applied to check the statistical significance in the Akaike information criterion (AIC) change, compared to the initial model
  2. Carbapenems: carbapenems consumption during the current quarter; Carblag-1: carbapenems consumption during the previous quarter; Merolag-1: meropenem consumption during the previous quarter; Meropenem: meropenem consumption during the current quarter; Penicillins: penicillins consumption during the current quarter; Penlag-1: penicillins consumption during the previous quarter; PipTazo: piperacillin + tazobactam consumption during the current quarter; PipTazolag-1: piperacillin + tazobactam consumption during the previous quarter; PsaCARB: incidence density of carbapenem-resistant P. aeruginosa strains during the current quarter; PsaCARBlag-1: incidence density of carbapenem-resistant P. aeruginosa strains during the previous quarter; PsaCR: incidence density of combined-resistant P. aeruginosa strains during the current quarter; PsaCRlag-1: incidence density of combined-resistant P. aeruginosa strains during the previous quarter