Triple combination antibiotic therapy for carbapenemase-producing Klebsiella pneumoniae: a systematic review

Jacobs, David M.; Safir, M. Courtney; Huang, Dennis; Minhaj, Faisal; Parker, Adam; Rao, Gauri G.

doi:10.1186/s12941-017-0249-2

Annals of Clinical Microbiology and Antimicrobials

Table 3 Patient-specific summary of demographics, clinical outcomes, and combination treatment by infection source among tier 1 articles

From: Triple combination antibiotic therapy for carbapenemase-producing Klebsiella pneumoniae: a systematic review

Infection	Patient no.	Age	bla	Co-infection	Treatment	Microbiological outcome	Mortality
Pneumonia	1	54	KPC	–	MER COL TIG	–	No
	2	67	VIM-1	–	MER COL TIG	–	No
	3	39	VIM-1	Bacteremia	MER COL TIG	–	No
	4	22	VIM-1	–	MER COL TIG	Failure	No
	5	52	KPC	–	GEN COL TIG	–	No
	6		KPC	–	GEN COL TIG	–	No
	7	68	KPC	–	GEN COL TIG	Failure	No
	8	19	KPC	–	GEN COL TIG	Failure	No
	9	57	KPC-2	UTI	GEN COL TIG	–	Yes
	10	63	KPC-2	–	GEN COL TIG	–	Yes
	11	52	KPC-2	–	FOS COL TIG	Success	No
	12	28	KPC-2	–	FOS COL TIG	Failure	No
	13	77	KPC-2	Bacteremia, SSI	ERT DOR PMB	Success	No
	14	62	KPC-2	–	ERT DOR COL PMB	Success	No
	15	62	KPC-2	Bacteremia	DOR GEN COL TIG	Success	No
	16	67	KPC-2	–	MER TIG RIF	Failure	Yes
	17	72	KPC-2	–	MER FOS COL	Failure	Yes
Urinary tract	18	75	OXA-48	Bacteremia	MER ERT COL	Success	No
	19	63	KPC-2	–	MER FOS COL	Failure	No
	20	68	–	–	MER FOS COL DOX	Failure	No
	21	33	–	–	MER FOS DOX	Success	No
	22	31	–	Bacteremia	MER COL TIG	Failure	No
	23	62	–	Bacteremia	FOS COL TIG	Failure	No
	24	54	KPC	Bacteremia	DOR GEN FOS COL	Failure	No
	25	61	KPC	Bacteremia	FOS TIG DOX	Failure	Yes
	26	70	KPC-2	Bacteremia	AMK COL TIG	–	Yes
Primary or catheter-related bacteremia	27	61	KPC-2	–	MER TIG CIP	Failure	No
	28	30	KPC-2	–	MER FOS COL	Success	No
	29	42	KPC-2	–	MER GEN COL	Success	Yes
	30	69	KPC-2	–	MER COL CIP	Success	No
	31	73	KPC-2	–	GEN FOS TIG	Success	No
	32	46	KPC-2	–	AMK COL TIG TZP	Success	Yes
	33	64	KPC-2	–	MER COL TIG	Failure	No
	34	55	KPC-2	–	MER COL TIG	Failure	Yes
	35	74	VIM-1	–	MER COL TIG	Failure	Yes
	36	63	KPC-2	–	FOS COL TIG	Failure	Yes
	37	65	KPC-2	–	COL CIP TZP	Failure	Yes
Intra-abdominal	38	44	KPC-2	Bacteremia	GEN COL TIG	Success	No
	39	60	KPC-2	Bacteremia, SSI	GEN COL TIG	Success	Yes
	40	38	KPC-2	–	GEN COL TIG	Success	No
	41	53	KPC-2	Bacteremia	GEN COL FOS	Success	Yes
	42	57	KPC	Bacteremia	GEN COL TIG	Failure	Yes
	43	75	KPC	Bacteremia	FOS COL TIG TZP	Failure	Yes
Peritonitis	44	63	KPC-2	–	AMK TIG CIP	Failure	No
	45	61	KPC-2	–	AMK COL TIG	Success	No
	46	27	KPC-2	Cholangitis	GEN COL TIG	–	Yes
	47	55	KPC-2	–	AMK TZP SMT	Success	No
Surgical site	48	70	KPC-2	Bacteremia	AMK COL TIG		Yes
Surgical site	49	34	KPC-2	–	ERT FOS COL	Success	No
Ventriculitis	50	43	KPC-2	–	AMK GEN COL TIG	Success	No
Meningitis	51	18	OXA-48	–	FOS COL TZP	Success	No
Lower respiratory	52	39	OXA-48	–	AMK COL TIG	–	No
Prosthetic joint	53	58	KPC	–	AMK COL TIG	Failure	Yes

bla beta-lactamase, SSI surgical site infection, UTI urinary tract infection, AMK amikacin, CIP ciprofloxacin, COL colistin, DOR doripenem, DOX doxycycline, ERT ertapenem, FOS fosfomycin, GEN gentamicin, MER meropenem, PMB polymyxin B, RIF rifampin, SMT sulfamethoxazole/trimethoprim, TIG tigecycline, TZP piperacillin/tazobactam

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ISSN: 1476-0711

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