Fig. 4

Effect of sessile and planktonic Candida on antiviral drug activity. Antiviral effect of acyclovir and foscarnet on HSV-1 infected cells embedded or not (control) in C. albicans biofilm and also on infected cells incubated in the presence of planktonic C. albicans grown on a glass slide. Twenty-four hours old Candida cells grown either with or without a glass slide on the well bottom were co-cultured with HSV-1 infected VERO cells in acyclovir or foscarnet containing medium. After 24 h incubation, samples were frozen and thawed to lyse infected cells, then the released virus was end-point titrated. Controls (no biofilm) were run in parallel. *p > 0.05