Treating tuberculosis with high doses of anti-TB drugs: mechanisms and outcomes

Table 2 Low drug serum concentrations reported in different types of patients

Types of patients	Mechanisms	References
Common pulmonary TB with low-dose prescription	Some patients are underdosed even at standard doses	[75, 121,122,123,124]
Common pulmonary TB with low-dose prescription	Fixed-dose combination with at least one low drug level in the serum	[14, 15, 82, 125]
Patients with slow response to TB treatment	Low serum level of Cmax 2 h post-dose	[126]
Patients with difficult TB	Difficult to increase the drug serum level	[106]
Patients with TB and HIV	Poor exposure to anti-TB drugs	[127, 128]
Patients with TB and HIV	Interaction between anti-HIV and anti-TB drugs	[129]
Patients with TB and diabetes mellitus	Decreased exposure to anti-TB drugs	[130]
Patients with TB and diabetes mellitus	Differences in hepatic induction	[131]

ISSN: 1476-0711