Table 1 Summary of the WHO-recommended doses and the high doses recommended by clinical trials
From: Treating tuberculosis with high doses of anti-TB drugs: mechanisms and outcomes
Drugs | WHO-recommended dose | Recommended high dose | ||||
|---|---|---|---|---|---|---|
Daily | Three times per week | Daily dose | ||||
Dose and range (mg/kg body weight) | Maximum (mg) | Dose and range (mg/kg body weight) | Daily maximum (mg) | Dose and range (mg/kg body weight) | Maximum (mg) | |
Isoniazid | 5 (4–6) | 300 | 10 (8–12) | 900 | 16–18 |  |
Rifampicin | 10 (8–12) | 600 | 10 (8–12) | 600 |  | 900–1200 |
Pyrazinamide | 25 (20–30) | – | 35 (30–40) | – |  |  |
Ethambutol | 15 (15–20) | – | 30 (25–35) | – | 25 |  |
Streptomycin | 15 (12–18) | a | 15 (12–18) | 1000 |  |  |
Kanamycin | 15 | 1000 | The same dose during the continuation phase | Â | Â | |
Amikacin | 15–20 | 1000 | The same dose during the continuation phase |  |  | |
Capreomycin | 15–20 | 1000 | The same dose during the continuation phase |  |  | |
Ciprofloxacin | 1000–1500 |  | – |  |  |  |
Cycloserine E | 10–15 | 1000 | – |  |  |  |
Ethionamide | 15–20 | 1000 | – |  |  |  |
Gatifloxacin | 400 | – | – |  |  |  |
Levofloxacin | 750 | 1000 | – |  | 17–20 | 1000 |
Moxifloxacin, | 400 | – | – |  |  | 600 |
Ofloxacin | 800 | – | – |  |  |  |
p-Aminosalicylate | 150 | 12,000 | – |  |  |  |