Table 8 Analysis of patients with ≥2 drug levels
From: Voriconazole and posaconazole therapeutic drug monitoring: a retrospective study
Comparison action taken on an initial non-therapeutic drug level | Survive to hospital discharge (n = 59) | Did not survive to hospital discharge (n = 20) | OR | p |
|---|---|---|---|---|
A dose adjustment was made | 24 (41) | 8 (40) | 1.03 (0.4–2.9) | 1.00 |
No dose adjustment was made | 35 (59) | 12 (60) | Â | Â |
| Â | Therapeutic drug level | Non-therapeutic drug level | OR (95% CI) | p |
|---|---|---|---|---|
Overall | (n = 29) | (n = 50) |  |  |
 A dose adjustment was made (no. [%]) | 17 (59) | 15 (30) | 3.31 (1.3–8.6) | 0.02 |
 No dose adjustment was made (no. [%]) | 12(41) | 35 (70) |  |  |
First level prior to steady statea | (n = 9) | (n = 23) |  |  |
 Dose adjustment made (no. [%]) | 4 (44) | 7 (30) | 1.83 (0.4–8.9) | 0.68 |
 No dose adjustment made (no. [%]) | 5 (56) | 16 (70) |  |  |
First level at steady statea | (n = 20) | (n = 27) |  |  |
 Dose adjustment made (no. [%]) | 13 (65) | 8 (30) | 4.41 (1.3–15.2) | 0.02 |
 No dose adjustment made (no. [%]) | 7 (35) | 19 (70) |  |  |
First level measured after ≥3 days | (n = 28) | (n = 44) |  |  |
 Dose adjustment made (no. [%]) | 16 (57) | 14 (32) | 2.86 (1.1–7.6) | 0.049 |
 No dose adjustment made (no. [%]) | 12 (43) | 30 (68) |  |  |