PknB remains an essential and a conserved target for drug development in susceptible and MDR strains of M. Tuberculosis

Gupta, Anamika; Pal, Sudhir K.; Pandey, Divya; Fakir, Najneen A.; Rathod, Sunita; Sinha, Dhiraj; SivaKumar, S.; Sinha, Pallavi; Periera, Mycal; Balgam, Shilpa; Sekar, Gomathi; UmaDevi, K. R.; Anupurba, Shampa; Nema, Vijay

doi:10.1186/s12941-017-0234-9

Annals of Clinical Microbiology and Antimicrobials

Table 1 Demographic and laboratory profile of the isolates used

From: PknB remains an essential and a conserved target for drug development in susceptible and MDR strains of M. Tuberculosis

Sr. no.	Study no.	HIV	Age	Sex	Collection date	Drug susceptibility profile (MGIT)	Spoligotype	Mutations in pknB gene
1	N1	N	35	F	6/3/2006	Susceptible	T1-53	Nil
2	N2	N	50	F	17/03/2006	Susceptible	Orphan	Nil
3	N3	N	30	M	24/03/2006	Susceptible	EAI5-355	Nil
4	N4	N	50	M	27/03/2006	Susceptible	EAI3_IND-11	Nil
5	N5	N	22	F	29/03/2006	Susceptible	CAS1_DELHI-26	Nil
6	N6	N	38	M	28/04/2006	Susceptible	CAS1_DELHI-26	Nil
7	N7	N	55	F	8/5/2006	Susceptible	CAS-486	Nil
8	N8	N	29	F	15/06/2006	Susceptible	CAS-357	Nil
9	N9	N	23	M	16/06/2006	Susceptible	MANU2-1634	Nil
10	N10	N	23	M	19/06/2006	Susceptible	EAI5-126	Nil
11	N11	N	40	F	27/06/2006	Susceptible	CAS1_DELHI-427	Nil
12	N12	N	28	M	29/06/2006	Susceptible	T3-37	Nil
13	N13	N	40	M	29/06/2006	Susceptible	CAS1_DELHI-25	Nil
14	N14	N	24	M	10/10/2006	Susceptible	CAS1_DELHI-26	Nil
15	N15	N	22	M	20/10/2006	Susceptible	EAI1_SOM-48	Nil
16	N16	N	25	F	11/5/2006	S,H	T2-52	664 (GTC-ATC)
17	N17	N	32	M	5/7/2006	S,H,R	Orphan	Nil
18	N18	N	30	M	12/9/2006	S,H,R	CAS2-288	Nil
19	N19	N	21	M	22/09/2006	S,H	T3-37	Nil
20	N20	N	27	M	27/09/2006	S	Orphan	Nil
21	N21	N	42	M	31/10/2006	S	EAI5-126	Nil
22	N22	N	26	M	15/01/2007	S,H	Orphan	Nil
23	N23	N	21	M	18/01/2007	H	H3-99	Nil
24	N24	N	38	M	22/01/2007	S,H,E	CAS1_DELHI-26	Nil
25	N25	N	45	F	31/01/2007	H	CAS1_DELHI-26	Nil
26	N26	P	32	M	7/2/2007	S,H,R	T2-1077	Nil
27	N27	P	40	M	7/3/2007	S,H	CAS2-288	Nil
28	N28	N	50	M	8/3/2007	S	H3-99	Nil
29	N29	P	35	M	8/3/2007	H	Orphan	Nil
30	S1	NT	35	M	27/03/2013	Susceptible	CAS1_DELHI-26	Nil
31	S2	NT	27	M	3/4/2013	Susceptible	T1-53	Nil
32	S3	NT	50	M	3/4/2013	Susceptible	Orphan	Nil
33	S4	NT	24	M	3/4/2013	H,R,E,OFX	Orphan	Nil
34	S5	NT	38	M	4/4/2013	S,H,R,E	BEIJING-1	Nil
35	S6	NT	45	M	5/4/2013	R,H	T1-53	Nil
36	S7	NT	31	M	8/4/2013	Susceptible	T1-53	Nil
37	S8	NT	50	M	3/4/2013	R,H	CAS1_DELHI-1789	Nil
38	S9	NT	35	M	8/4/2013	Susceptible	Orphan	Nil
39	S10	NA	55	M	8/4/2013	OFX	MANU1-100	Nil
40	S11	NA	NA	NA	NA	S,H,E,OFX	BEIJING-1	Nil
41	S12	P	40	F	2012–2013	Susceptible	EAI3_IND-11	Nil
42	S13	P	NA	NA	2012–2013	Susceptible	CAS1_DELHI-26	Nil
43	S14	P	35	M	2012–2013	Susceptible	CAS1_DELHI-26	Nil
44	S15	P	48	F	2012–2013	H	CAS1_DELHI-26	Nil
45	S16	P	26	M	2012–2013	H,R	CAS1_DELHI-26	Nil
46	S17	P	30	F	2012–2013	H	CAS1_DELHI-26	Nil
47	S18	P	31	M	2012–2013	H,R,OFX	Orphan	Nil
48	S19	P	36	M	2012–2013	H	Orphan	Nil
49	S20	P	23	M	2012–2013	H	Orphan	Nil
50	C1	NT	NA	NA	2013	R,H, OFX	T5-1268	Nil
51	C2	NT	NA	NA	2013	R,H	EAI3_IND-11	Nil
52	C3	NT	NA	NA	2013	R,H	BEIJING-1	Nil
53	C4	NT	NA	NA	2013	R,H,OFX	Orphan	Nil
54	C5	NT	NA	NA	2013	R,H	Orphan	Nil
55	C6	NT	NA	NA	2013	R,H,OFX	CAS1_DELHI-381	Nil
56	C7	NT	NA	NA	2013	R,H	T1–T2-78	Nil
57	C8	NT	NA	NA	2013	R,H,OFX	T2-52	Nil
58	C9	NT	NA	NA	2013	R,H,OFX	Orphan	Nil
59	C10	NT	NA	NA	2013	R,H,OFX	Orphan	Nil
60	C11	NT	NA	NA	2013	R,H	T1-53	Nil
61	C12	NT	NA	NA	2013	R,H	Orphan	Nil
62	C13	NT	NA	NA	2013	S,H,R,E,OFX	Orphan	Nil
63	C14	NT	NA	NA	2013	Susceptible	CAS1_DELHI-26	Nil
64	C15	NT	NA	NA	2013	S,H,E	T2-52	Nil
65	C16	NT	NA	NA	2013	S,H,R,E	Bejing-1	Nil
66	C17	NT	NA	NA	2013	S,E	CAS1_DELHI-26	Nil
67	C18	NT	NA	NA	2013	S,E	Orphan	Nil
68	C19	NT	NA	NA	2013	S	Orphan	Nil
69	C20	NT	NA	NA	2013	S	Orphan	Nil
70	C21	NT	NA	NA	2013	Susceptible	EA15-934	Nil
71	C22	NT	NA	NA	2013	S,H,R,E	EA15-934	Nil
72	C23	NT	NA	NA	2013	Susceptible	EAI3_IND-11	Nil
73	C24	NT	NA	NA	2013	Susceptible	Orphan	Nil
74	C25	NT	NA	NA	2013	Susceptible	Bejing-1	Nil
75	C26	NT	NA	NA	2013	S,H,R,E		Nil
76	C27	NT	NA	NA	2013	Susceptible	T1-804	Nil
77	C28	NT	NA	NA	2013	H	EAI3_IND	Nil
78	C29	NT	NA	NA	2013	Susceptible	EAI3_IND	Nil
79	C30	NT	NA	NA	2013	S,H,R,E,OFX	Orphan	Nil
80	C31	NT	NA	NA	2013	Susceptible	Orphan	Nil
81	C32	NT	NA	NA	2013	Susceptible	CAS1_DELHI	Nil
82	C33	NT	NA	NA	2013	S,H, OFX	Bejing-1	Nil
83	C34	NT	NA	NA	2014	Susceptible	EAI3_IND-11	Nil
84	C35	NT	NA	NA	2014	S,H,OFX	Orphan	Nil
85	C36	NT	NA	NA	2014	OF	U-1391	Nil
86	C37	NT	NA	NA	2014	Susceptible	EAI3_IND-11	Nil
87	C38	NT	NA	NA	2014	Susceptible	EAI3_IND-11	Nil
88	C39	NT	NA	NA	2014	R	EAI3_IND-11	Nil
89	C40	NT	NA	NA	2014	Susceptible	Orphan	Nil
90	C41	NT	NA	NA	2014	Susceptible	EAI3_IND-11	Nil
91	B1	N	18	F	2013–2014	S,H,R,E,OFX	BEIJING-1	Nil
92	B2	N	20	M	2013–2014	S,H,R,E,OFX	H1-47	Nil
93	B3	P	25	F	2013–2014	S	LAM2–LAM4-194	Nil
94	B4	N	25	M	2013–2014	S,H,R,E, OFX	LAM-9	Nil
95	B5	N	40	M	2013–2014	S,H	CAS2-288	Nil
96	B6	N	25	M	2013–2014	Susceptible	Orphan	Nil
97	B7	N	47	M	2013–2014	S,H,R,E	Orphan	Nil
98	B8	N	30	M	2013–2014	S,H,R,E	BEIJING-1	Nil
99	B9	N	20	M	2013–2014	S,H,R,E,OFX	T1-53	Nil
100	B10	N	21	M	2013–2014	H,R	Orphan	Nil
101	B11	N	45	M	2013–2014	H,R,OFX	BEIJING-1	Nil
102	B12	N	23	M	2013–2014	S,H	T1-53	Nil
103	B13	N	23	M	2013–2014	Susceptible	EAI1_SOM-235	Nil
104	B14	N	22	F	2013–2014	S,H,R,OFX	CAS1_DELHI	Nil
105	B15	N	22	F	2013–2014	S,H,R,E,OFX	CAS1_DELHI	Nil
106	B16	N	70	M	2013–2014	H,R,OFX	Orphan	Nil
107	B17	N	9	F	2013–2014	H,R,E,OFX	BEIJING-1	Nil
108	B18	N	19	M	2013–2014	H,R,E	Orphan	Nil
109	B19	N	25	F	2013–2014	H	T1-53	Nil
110	B20	P	45	F	2013–2014	Susceptible	BEIJING-1	Nil
111	B21	N	30	F	2013–2014	S,H,R,E,OFX	BEIJING-1	Nil
112	B22	N	18	F	2013–2014	S,H,R,E,OFX	BEIJING-1	Nil
113	B23	N	46	F	2013–2014	S	Orphan	Nil
114	B24	N	50	M	2013–2014	H,R,OFX	BEIJING-1	Nil
115	B25	N	NA	NA	2013–2014	OFX	T1-1567	Nil
116	B26	N	NA	NA	2013–2014	H,S	U-172	Nil

N1–N29 isolates obtained from NARI, Pune; S1–S20 isolates obtained from STDC, Pune, Maharashtra; C1–C40 isolates obtained from NIRT, Chennai, Tamil Nadu; B1–B26 isolates obtained from BHU, Varanasi, Uttar Pradesh
NIRT National Institute for Research in Tuberculosis, BHU Banaras Hindu University, STDC State TB Training and Demonstration Centre, S resistant to streptomycin, H resistant to isoniazid, R resistant to rifampicin, E resistant to ethambutol, OFX resistant to ofloxacin, N negative, NT not tested, NA information not available

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