Table 5 Adjusted linear relationship between the relative change of PT-INR and the difference in daptomycin concentrations between the trough and peak
Reagent | Adjusted β (95% CI) (/μg/mL) | p value | p value for interaction | r2 |
|---|---|---|---|---|
H0: β = 0 | ||||
1 | 5.1 × 10−4 (−9.5 × 10−4–2.0 × 10−3) | 0.48 | 0.02 | |
Warfarin (+) | 1.2 × 10−3 (−1.3 × 10−3–3.7 × 10−3) | 0.34 | 0.79 | 0.03 |
Warfarin (−) | 2.0 × 10−4 (−1.7 × 10−3–2.1 × 10−3) | 0.83 | ||
2 | 2.3 × 10−3 (−1.1 × 10−4–5.0 × 10−3) | 0.06 | 0.33 | |
Warfarin (+) | 6.4 × 10−3 (3.5 × 10−3–9.3 × 10−3) | <0.001 | 0.0003 | 0.57 |
Warfarin (−) | 4.2 × 10−4 (−1.6 × 10−3–2.5 × 10−3) | 0.68 | ||
3 | 3.3 × 10−3 (5.2 × 10−4–6.0 × 10−3) | 0.02 | 0.34 | |
Warfarin (+) | 8.3 × 10−3 (4.4 × 10−3–1.2 × 10−2) | <0.001 | 0.001 | 0.56 |
Warfarin (−) | 9.8 × 10−4 (−1.2 × 10−3–3.2 × 10−3) | 0.36 | ||
4 | 8.5 × 10−4 (−2.5 × 10−4–2.0 × 10−3) | 0.13 | 0.08 | |
Warfarin (+) | 1.4 × 10−3 (−1.1 × 10−3–3.9 × 10−3) | 0.26 | 0.52 | 0.10 |
Warfarin (−) | 5.6 × 10−4 (−6.1 × 10−4–1.7 × 10−3) | 0.33 | ||
5 | −1.8 × 10−4 (−9.2 × 10−4–5.7 × 10−4) | 0.63 | 0.009 | |
Warfarin (+) | 2.3 × 10−4 (−7.1 × 10−4–1.2 × 10−3) | 0.63 | 0.78 | 0.03 |
Warfarin (−) | −4.0 × 10−4 (−1.4 × 10−3–6.5 × 10−4) | 0.44 | ||
6 | 4.4 × 10−4 (−7.3 × 10−4–1.6 × 10−3) | 0.45 | 0.03 | |
Warfarin (+) | 1.7 × 10−3 (−4.7 × 10−4–3.8 × 10−3) | 0.12 | 0.45 | 0.09 |
Warfarin (−) | −1.4 × 10−4 (−1.5 × 10−3–1.2 × 10−3) | 0.84 | ||
7 | −3.3 × 10−5 (−2.1 × 10−3–2.0 × 10−3) | 0.97 | 0.006 | |
Warfarin (+) | −1.1 × 10−3 (−5.9 × 10−3–3.8 × 10−3) | 0.65 | 0.81 | 0.03 |
Warfarin (−) | 4.4 × 10−4 (−1.3 × 10−3–2.2 × 10−3) | 0.61 | ||
8 | −2.1 × 10−4 (−2.2 × 10−3–1.8 × 10−3) | 0.83 | 0.02 | |
Warfarin (+) | −1.0 × 10−3 (−5.6 × 10−3–3.5 × 10−3) | 0.65 | 0.72 | 0.04 |
Warfarin (−) | 1.5 × 10−4 (−1.7 × 10−3–2.0 × 10−3) | 0.87 | ||
9 | 2.6 × 10−4 (−1.1 × 10−3–1.7 × 10−3) | 0.71 | 0.03 | |
Warfarin (+) | 2.1 × 10−3 (−7.9 × 10−4–4.9 × 10−3) | 0.15 | 0.32 | 0.12 |
Warfarin (−) | −5.6 × 10−4 (−2.1 × 10−3–9.6 × 10−4) | 0.46 |