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Table 4 Linear relationship between the relative change of PT-INR and the difference in daptomycin concentrations between the trough and peak

From: Dose-dependent artificial prolongation of prothrombin time by interaction between daptomycin and test reagents in patients receiving warfarin: a prospective in vivo clinical study

Reagent n Unadjusted β (95% CI) (/μg/mL) p value r2
H0: β = 0
1 34 5.1 × 10−4 (−9.2 × 10−4–1.9 × 10−3) 0.48 0.02
2 34 2.2 × 10−3 (−5.6 × 10−4–4.9 × 10−3) 0.12 0.15
3 34 3.1 × 10−3 (2.3 × 10−5–6.3 × 10−3) 0.048 0.19
4 34 8.5 × 10−4 (−2.2 × 10−4–1.9 × 10−3) 0.12 0.08
5 32 −1.8 × 10−4 (−9.2 × 10−4–5.6 × 10−4) 0.62 0.006
6 33 4.3 × 10−4 (−7.3 × 10−4–1.6 × 10−3) 0.45 0.02
7 33 −5.0 × 10−5 (−2.0 × 10−3–1.9 × 10−3) 0.96 <0.001
8 34 −2.3 × 10−4 (−2.1 × 10−3–1.6 × 10−3) 0.80 0.003
9 34 2.3 × 10−4 (−1.1 × 10−3–1.6 × 10−3) 0.73 0.003